天津科技大学生物工程学院欢迎您!
副教授

张会图,博士,男,副教授,硕士生导师,中国协和医科大学博士,美国德克萨斯州农机大学(Texas A&M University)化学系博士后,中国医药生物技术学会理事,天津市“三年千人”第三层次人才。


主讲课程:
本科生:《基因工程》,《微生物遗传育种实验》
主要教学研究及成果情况


参编教材1部:
[1]《生物制药工艺学》,人民卫生出版社。


科研领域及方向
[1] 微生物药物的筛选、分离、鉴定,以及微生物药物(抗生素)的生物合成、代谢调控及组合生物合成等
[2] 工业微生物的菌种改良以及工业酶制剂的开发及产业化应用


科研项目情况
[1] 863计划(子任务):工程菌小试发酵及后加工工艺研究,2012-2017。
[2] 国家自然科学基金面上项目:非昔罗霉素的生物合成及组合生物合成研究,2013-2017。
[3] 天津市科技计划项目:采用反转录PCR的方式进行安莎类抗生素的筛选,2012-2015。
[4] 企业横向合作项目:恩拉霉素高产菌株的选育及产业化研究,2012-2015。
[5] 企业横向合作项目:新霉素、金霉素高产菌株的选育及发酵工艺研究,2018-2020。


主要学术成果
先后发表各类科研论文20余篇,授权发明专利4项。发表的主要学术论文有:
[1] He X, Li M, Song S, Wu X, Zhang J, Wu G, Yue R, Cui H, Song S, Ma C, Lu F, Zhang H. Ficellomycin: an aziridine alkaloid antibiotic with potential therapeutic capacity. APPL MICROBIOL BIOTECHNOL. 2018 May; 102(10):4345-4354. (通讯作者)
[2]  Liu Y, Li M, Mu H, Song S, Zhang Y, Chen K, He X, Wang H, Dai Y, Lu F, Yan Z, Zhang H. Identification and characterization of the ficellomycin biosynthesis gene cluster from Streptomyces ficellus. APPL MICROBIOL BIOTECHNOL. 2017 Oct; 101(20):7589-7602. (通讯作者)
[3] Chen K, Mo Q, Liu H, Yuan F, Chai H, Lu F, Zhang H. Identification and characterization of a novel cold-tolerant extracellular protease from Planococcus sp. CGMCC 8088. EXTREMOPHILES. 2018 May; 22(3):473-484. (通讯作者)
[4] Mori S, Simkhada D, Zhang H, Erb MS, Zhang Y, Williams H, Fedoseyenko D, Russell WK, Kim D, Fleer N, Ealick SE, Watanabe CM. Polyketide Ring Expansion Mediated by a Thioesterase, Chain Elongation and Cyclization Domain, in Azinomycin Biosynthesis: Characterization of AziB and AziG. BIOCHEMISTRY. 2016; 55(4):704-714. (并列第一作者)
[5] Huitu Zhang, Huiyan Mu, Qingshan Mo, Tongwei Sun, Yang Liu, Mingyu Xu, Haikuan Wang, Yujie Dai, Fuping Lu. Gene cloning, expression and characterization of a novel cold-adapted protease from Planococcus sp. JOURNAL OF MOLECULAR CATALYSIS B: ENZYMATIC. 2016; 130: 1-8.
[6] Zhang Huitu, Tian Y, Wang J, Li Y, Wang H, Mao S, Liu X, Wang C, Bie S, Lu F. Construction of engineered Arthrobacter simplex with improved performance for cortisone acetate biotransformation. APPL MICROBIOL BIOTECHNOL. 2013; 97(21): 9503-9514.
[7] Lu H, Zhang Huitu, Shi P, Luo H, Wang Y, Yang P, Yao B. A family 5 β-mannanase from the thermophilic fungus Thielavia arenaria XZ7 with typical thermophilic enzyme features. APPL MICROBIOL BIOTECHNOL. 2013 Sep; 97(18): 8121-8128. (通讯作者)
[8] Simkhada D, Zhang Huitu, Mori S, Williams H, Watanabe CM. Activation of cryptic metabolite production through gene disruption: Dimethyl furan-2,4-dicarboxylate produced by Streptomyces sahachiroi. BEILSTEIN J ORG CHEM. 2013 Aug; 9:1768-1773.
[9] Cao Y, He S, Zhou Z, Zhang M, Mao W, Zhang Huitu, Yao B. Orally administered thermostable N-acyl homoserine lactonase from Bacillus sp. strain AI96 attenuates Aeromonas hydrophila infection in zebrafish. APPL ENVIRON MICROBIOL. 2012 Mar; 78(6):1899-1908.
[10] Junqi Zhao1, Pengjun Shi1, Yingguo Bai1, Huoqing Huang1, Huiying Luo1, Huitu Zhang2,* Donghao Xu1, Yaru Wang1, Bin Yao1.*A thermophilic cellulase complex from phialophora sp. G5 showing high capacity in cellulose hydrolysis. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 2012, 166 (4), 952-960. (通讯作者).
[11] Guanglin wang1, Huitu Zhang1, Guizhi Sun2, Linzhuan Wu2, Jinchi Zhang1 and Yiguang Wang. A new method for rapid identification of ansamycin compounds by inactivating KLM gene clusters in potential ansamycin-producing actinomyces. JOURNAL OF APPLIED MICROBIOLOGY. 2011, 112(2), 353-362.
[12] Jennifer Foulke-Abel, Gilbert T. Kelly, Huitu Zhang and Coran Watanabe. Characterization of AziR, a resistance protein of the DNA cross-linking agent azinomycin B. MOLECULAR BIOSYSTEMS. 2011, 7(9), 2563-2570.
[13] Foulke-Abel J, Agbo H, Huitu Zhang, Mori S, Watanabe CM. Mode of action and biosynthesis of the azabicycle-containing natural products azinomycin and ficellomycin. NATURAL PRODUCT REPORTS. 2011, 28(4), 693-704. 
[14] Huitu Zhang, Wu linzhuan, Liu Aiming, Sun Guizhi, Han Feng, Xia Huanzhang, Gao Qunjie,Yonggang Wangiguang. PCR screening of 3-amino- 5-hydroxybenzoic acid synthase gene leads to identification of ansamycins and AHBA related antibiotic producers in Actinomycetes. JOURNAL OF APPLIED MICROBIOLOGY. 2009, 106(3), 755-763. 
[15] 王建玲, 许铭玉, 石天歌, 安兴娟, 张紫音, 程思, 姬阿美, 马翠萍, 高爽, 王应东, 张会图. 紫外诱变选育恩拉霉素高产菌株. 工业微生物. 2015, 45(5), 23-28. 
[16] 牟慧艳, 刘扬, 王应东, 刘宝爱, 魏建军, 张会图. 恩拉霉素生产菌株的遗传改造. 微生物学通报. 2017, 44(1): 126−132. 
[17] 许铭玉, 宋淑婷, 张莹, 张会图. 恩拉霉素生物检测方法的改进. 中国畜牧兽医. 2017, 44(2), 384-390. 
授权发明专利主要有:
张会图,王应东,路福平,刘东田,魏建军. 一种恩拉霉素高产菌株的构建方法. CN2015100329738
路福平, 张会图, 冯士元. 一种具备转酯功能和耐酸抗蛋白酶特性的猪胰腺羧肽酶A1. CN201510059312
路福平, 田曜, 张会图, 王克鼎. 一种适用于芽孢杆菌属同源重组的质粒及工程菌株. ZL201310262705.6


联系方式
办公地点:天津经济技术开发区第十三大街29号天津科技大学生物工程学院
邮政编码:300457
办公电话:022-60601958
传 真:022-60602298
Email: hzhang@tust.edu.cn

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