天津科技大学生物工程学院欢迎您!
副教授


董健,博士,博士后,天津科技大学生物工程学院副研究员,硕士生导师。

科研领域及方向 

[1]酿造酒(白酒、啤酒)用酵母、面包酵母、燃料乙醇酵母育种以及菌种工业应用;

[2]真核细胞信号转导理论研究:以真核细胞模式生物——芽殖酵母为研究对象,研究环腺苷酸信号通路调控和反馈抑制分子机制。

科研情况 

[1] 国家自然科学基金面上项目酿酒酵母蛋白激酶A催化亚基抑制环腺苷酸合成的调控机制研究,主持人,63, 2017.01-2020.12

[2] 国家自然科学基金青年项目: 酿酒酵母蛋白激酶A催化亚基细胞定位对其功能特异性的调控机制研究,主持人,23万, 2014.01-2016.12

[3] 天津市高等学校科技发展基金计划项目:酿酒酵母酯合成代谢机理研究与适量高产酯菌种的选育,主持人,4万,2011.11-2013.7

[4] 国家自然科学基金面上项目:胁迫条件下酿酒酵母蛋白酶A胞外分泌机制研究,第二主持人,85万,2013.01 -2016.12

[5] 天津市科委应用基础及前沿技术研究计划项目:耐冷冻面包酵母基因工程菌种的选育,第二主持人,20万,2010.04 -2013.03

[6] 天津科技大学科学研究基金:酿酒酵母腺苷酸环化酶对细胞胁迫耐受性调控机制研究,主持人,0.5万,2012.12-2014.06

主要学术成果 

[1] Jian Dong Didi Chen Guanglu Wang Cuiying Zhang Liping DuShanshan LiuYu Zhao Dongguang Xiao*Improving freeze.tolerance of baker’s yeast through seamless gene deletion of NTH1 and PUT1Journal of Industrial Microbiology & Biotechnology, Vol.43, 2016, pp 817–828

[2] Jian Dong, Haiyan Xu, Libin Zhao,Yefu Chen,Cuiying Zhang,Xuewu Guo, Xiaoyue Hou, Didi Chen, Chenxi Zhang, Dongguang Xiao*. Enhanced acetate ester production of Chinese liquor yeast by overexpressing ATF1 through precise and seamless insertion of PGK1 promoter, Journal of Industrial Microbiology & Biotechnology, Vol.41, 2014, pp 1823-1828.

[3] Jian Dong, Guanglu Wang, Cuiying Zhang, Haigang Tan, Xi Sun, Mingyue Wu, Dongguang Xiao*. A two-step integration method for seamless gene deletion in baker’s yeast, Analytical Biochemistry, Vol. 439, 2013, pp 30–36.

[4] Jian Dong, Xiaojia Bai, The membrane localization of Ras2p and the association between Cdc25p and Ras2-GTP are regulated by Protein Kinase A (PKA) in the yeast Saccharomyces cerevisiae, FEBS Letters, Vol. 585, 2011, pp. 1127-1134.

[5] Jian Dong, Aili Zhang, Xiaojia Bai, Huansheng Zhao, Yun Hu, Feedback regulation of Ras2 guanine nucleotide exchange factor (Ras2-GEF) activity of Cdc25p by Cdc25p phosphorylation in the yeast Saccharomyces cerevisiae, FEBS Letters, Vol. 584, 2010, pp. 4745-4750.

[6] Xiaojia Bai*, Jian Dong, Serine214 of Ras2p plays a role in the feedback regulation of the Ras-cAMPpathway in the yeast Saccharomyces cerevisiae, FEBS Letters, Vol. 584, 2010, pp. 2333-2338.

联系方式 

办公地点:天津经济技术开发区第十三大街29号天津科技大学生物工程学院,

邮政编码:300457

办公电话:022-60602723 

真:022-60602298

Email: dongjian@tust.edu.cn

 

您是第1855382位访客