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讲师


刘振兴,博士,助理研究员,硕士研究生导师2014年获中国农业大学博士学位。 

主讲课程分子生物学(本科生);高等分子生物学(研究生)

科研领域及方向 

1.      转录因子TFEB自噬-溶酶体通路中的功能作用及其分子调控机制。 

2.      利用微生物代谢产物、天然产物、化学合成小分子等筛选自噬调控剂,并在肿瘤神经退行性疾病模型中探究其应用价值。 

科研项目

主持天津市教委科研计划项目1项(2017KJ007),参加国家重点研发计划项目2项(2017YFD04003002018YFD0400500)。

发表论文 

1. Zhenxing Liu, Zhichen Shi, Jieru Lin, Shuang Zhao, Min Hao, Junting Xu, Yuyin Li, Qing Zhao, Li Tao, Aipo Diao*, Piperlongumine-induced nuclear translocation of the FOXO3A transcription factor triggers BIM-mediated apoptosis in cancer cells, Biochemical Pharmacology, 2019, 163:101-110

2. Wei Li, Jieru Lin, Zhichen Shi, Jiren Wen, Yuyin Li, Zhenxing Liu*, Aipo Diao*, Clomiphene citrate induces nuclear translocation of the TFEB transcription factor and triggers apoptosis by enhancing lysosomal membrane permeabilization, Biochemical Pharmacology, 2019, 162:191-201

3. Zhenxing Liu, Xin Huo, Shuang Zhao, Jingjing Yang, Wenxia Shi, Lei Jing, Wei Li, Yuyin Li, Long Ma, Yingtang Gao, Aipo Diao*, Low density lipoprotein receptor class A domain containing 4 (LDLRAD4) promotes tumorigenesis of hepatic cancer cells, Exp Cell Res, 2017, 360(2): 189-198

4. Zhenxing Liu, Yingzheng Wang, Shuan Zhao, Jingyou Zhang, Yi Wu, Shenming Zeng*, Imidazole inhibits autophagy flux by blocking autophagic degradation and triggers apoptosis via increasing FoxO3a-Bim expression, Int J Oncol, 2015, 46(2): 721-731

5. Zhenxing Liu, Shuan Zhao, Shuaishuai Wu, Jingyou Zhang, Zunyang Nie, and Shenming Zeng*, A novel role of transient receptor potential mucolipin1 (TRPML1) in protecting against imidazole-induced cytotoxicity, Biochem Cell Biol, 2014, 92(4): 279-286

 

联系方式 

办公地点:天津经济技术开发区第十三大街29 

天津科技大学生物工程学院300457 

办公电话:022-60602948 

传真:022-60602298 

Emailliuzx@tust.edu.cn 

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