天津科技大学生物工程学院欢迎您!
副教授


申雁冰,博士,天津科技大学生物工程学院副教授,硕士生导师。天津市“131”人才计划第三层次人选, 天津市“131”创新型人才团队和天津市创新人才推进计划重点领域创新团队成员,中国微生物学会会员入选首届天津市高校优秀青年教师资助计划


主讲课程:

本科生:《生物药物合成原理》,《生物制药工艺学》

研究生:《生物制药技术》


主要教学研究及成果情况

参与教改项目1项,参编专著1部。

[1] 天津市高等学校本科教学质量与教学改革研究计划项目:制药工程专业特色建设的综合改革与实践,2014-2016,参与

[2] 第二届全国大学生生命科学创新创业大赛全国二等奖指导教师,2017

[3] 第三届全国大学生生命科学创新创业大赛全国一等奖指导教师,2018


科研领域及方向:

[1] 具有重要医药价值的工业微生物菌种筛选与改良;

[2] 微生物细胞催化反应与过程调控。


科研项目情况:

[1] 国家自然科学基金项目:环糊精介质中甾体结构与微生物催化活性的关系和基于活化效应的作用机制研究,2015-2017项目主持人

[2] 天津市自然科学基金简单节杆菌 C1,2 位脱氢酶底物催化特异性机制研究及理性改造2018-2021,项目主持人

[3] 天津市科技特派员项目:基于环糊精和细胞共循环的甾体绿色生物转化工艺研究,2018-2019,项目主持人

[4] 天津市应用基础与前沿技术研究计划项目:环糊精介质中甾体结构与C1,2脱氢反应的变化规律及机制” 2013-2016项目主持人

[5] 天津市高等学校科技发展基金计划项目超分子介质生物催化中主体化合物的选择策略研究2012 -2015项目主持人

[6] 教育部科学技术研究重点项目AD生物合成关键酶KsdD的稳定性分析与菌株构建2014-2016,排名第二

[7] 国家863计划子课题生物法合成去氢胆固醇技术研究2011-2016

[8] 国家自然科学基金项目:Mycrobacterium neoaurum 生物合成AD的产物迁移机制与调控2013-2016,排名第二

[9] 天津市科技计划项目环糊精介质中甾体药物及中间体生物转化工艺中试2015-2018,排名第二

[10] 国家自然科学基金面上项目环糊精介质对微生物催化反应物质转运的影响及其调控2011-2013,主要完成人

[11] 天津市应用基础及前沿技术研究计划重点项目强心苷药物的微生物转化与活性筛选2008-2011主要完成人


主要学术成果:

先后发表各类科研论文50余篇,参编专著1部,授权或申请发明专利30余项。发表的主要学术论文有:

[1] Zhao YQ, Shen YB*, Ma S, Luo JM, Ouyang W, Zhou HJ, Tang R, Wang M*. Poduction of 5a-androstene-3, 17-dione from phytosterols by co-expression of 5a-reductase and glucose-6-phosphate dehydrogenase in engineered Mycobacterium neoaurum, Green Chemistry, 2019, 21, 1809-1815

[2] Zhou XL, Zhang Y, Shen YB*, Zhang X, Xu SP, Shang ZH, Xia ML, Wang M*, Efficient production of androstenedione by repeated batch fermentation in waste cooking oil media through regulating NAD+/NADH ratio and strengthening cell vitality of Mycobacterium neoaurumBioresource Technology, 2019, 279: 209-217.

[3] Tang R, Shen YB*, Wang M*, Zhou HJ, Zhao YQ. Highly efficient synthesis of boldenone from androst-4-ene-3,17-dione by Arthrobacter simplex and Pichia pastoris ordered biotransformation[J]. Bioprocess and Biosystems Engineering. 2019, 42(6), 933-940

[4] Tang R, Shen YB, Xia ML, Tu LN, Luo JM, Geng YH, Gao T, Zhou HJ, Zhao YQ, Wang M*. A highly efficient step-wise biotransformation strategy for direct conversion of phytosterol to boldenone. Bioresource Technology, 2019, 283:242250

[5] Shen YB, Niu LL, Yu ZQ, Wang M*, Shang ZH, Yang Y. Sodium alginate-grafted β-cyclodextrins as a matrix for immobilized Arthrobacter simplex for cortisone acetate biotransformation, Applied Surface Science, 2018,444:42-47.

[6] Liu JJ, Wang LF, Shen YB*, Su LQ, Wang M*. Effect of β-cyclodextrins Derivatives on Steroids Biotransformation by Arthrobacter simplex, Applied Biochemistry and Biotechnology, 2018, 185(4), 1004-1013.

[7] Su LQ, Shen YB*, Xia ML, Shang ZH, Xu SP, An XJ, Wang M*. Overexpression of cytochrome p450 125 in Mycobacterium: a rational strategy in the promotion of phytosterols biotransformation, Journal of Industrial Microbiology and Biotechnology, 2018, 45(10): 857-86.

[8] Su LQ, Shen YB*, Zhang WK, Gao T, Shang ZH, Wang M*. Cofactor engineering to regulate NAD+/NADH ratio with its application to phytosterols biotransformation[J]. Microbial Cell Factories, 2017, 16(1):182.

[9] Shen YB, Yu ZQ, Yang X, Wang F, Wang M*. A new technique for promoting cyclic utilization of cyclodextrins in biotransformation, Journal of Industrial Microbiology and Biotechnology, 2017,44(1):1-7.  

[10] Wang LF, Shen YB, Liu MJ, Tang R, Wang M*. Influence of imidazolium-based ionic liquids on the steroid biotransformation by Arthrobacter simplex[J]. Journal of Chemical Technology & Biotechnology, 2018,93(2):426-431.

[11] Qin N, Shen YB*, Yang X, Su LQ, Tang R, Li W, Wang M*. Site-directed mutagenesis under the direction of in-silico protein docking modeling reveals the active site residues of 3-ketosteroid-Δ1-dehydrogenase from Mycobacterium neoaurum, World Journal of Microbiology and Biotechnology, 2017,33:146.

[12] Su LQ , Shen YB*, Gao T, Luo JM, Wang M*. Improvement of AD biosynthesis and cofactors analysis response to enhanced oxygen transfer by oxygen vectors in Mycobacterium neoaurum TCCC11979, Applied Biochemistry and Biotechnology, 2017,182:1564-1574.

[13] Qiao YQ, Shen YB*, Huang W, Wang YP, Ren JJ, Xia T, Wang M. Biocatalyst-mediated production of 11α, 15α-dihydroxy derivatives of androst-1, 4-dien-3, 17-dione, Journal of Bioscience and Bioengineering, 2017,123(6):692-697.

[14] Tang R, Shen YB, Wang M*, Zhai Y, Gao Q. Highly chemoselective and efficient production of 2,6-difluorobenzamide using Rhodococcus ruber CGMCC3090 resting cells.[J]. Journal of Bioscience & Bioengineering, 2017,124 (6): 641-646.

[15] Shen YB, Wang LF, Liang JT, Tang R, Wang M*. Effects of two kinds of imidazolium-based ionic liquids on the characteristics of steroid-transformation Arthrobacter simplex[J]. Microbial Cell Factories, 2016, 15:118.

[16] Shen YB, Wang F, Wang YP, Zhao Q, Wang M*. Cyclic utilization of HP-b-CD in the bioconversion of cortisone acetate by Arthrobacter simplex[J]. Biotechnol Lett, 2016, 38: 597-602.

[17] Liu Y, Shen YB*, Qiao YQ, Su LQ, Li C, Wang M*. The effect of 3-ketosteroid-Δ1-dehydrogenase isoenzymes on the transformation of AD to 9α-OH-AD by Rhodococcus rhodochrous DSM43269[J]. Journal of Industrial Microbiology and Biotechnology, 2016, 43: 1303-1311.

[18] Liu Y, Cao F, Xiong H, Shen YB, Wang M*. Application of 2,4-Dinitrophenyl-hydrazine(DNPH) in High-Throughput Screening for Microorganism Mutants Accumulating 9α-Hydroxyandrost-4-ene-3,17-dione (9α-OHAD)[J]. PLOS ONE, 2016, 10(11).

[19] Shen YB, Liang JT, Li HN, Wang M*. Hydroxypropyl-β-cyclodextrin-mediated alterations in cell permeability, lipid and protein profiles of steroid-transforming Arthrobacter simplex[J]. Applied Microbiology and Biotechnology, 2015, 99(1): 387-397.

[20] Xie RL, Shen YB, Qin N, Wang YB, Su LQ, Wang M*. Genetic differences in ksdD influence on the ADD/AD ratio of Mycobacterium neoaurum[J]. Journal of Industrial Microbiology and Biotechnology, 2015, 42: 507-513.

[21] Chen X, Shen YB, Liang QK, Flavell R, Hong ZY, Yin ZN, Wang M*. Effect of Bavachinin and its derivatives on T cell differentiation[J]. International Immunopharmacology, 2014, 19(2): 399-404.

[22] Luo JM, Liang QK, Shen YB, Chen X, Yin ZN, Wang M*. Biotransformation of bavachinin by three fungal cell cultures[J]. Journal of Bioscience and Bioengineering, 2014, 117(2): 191-196.

[23] Shen YB, Wang M*, Li XD, Zhang JL, Sun H, Luo JM. Highly efficient synthesis of 5-cyanovaleramide by Rhodococcus ruber CGMCC3090 resting cells. Journal of Chemical Technology and Biotechnology. 2012, 87: 1396-1400. 

[24] Shen YB, Wang M*, Li HN, Wang YB, Luo JM. Influence of hydroxypropyl-β-cyclodextrin on phytosterol biotransformation by different strains of Mycobacterium neoaurum. Journal of Industrial Microbiology and Biotechnology. 2012, 39(9), 1253-1259.

[25] Cui LY, Shen YB, Guo XD,Wang YZ, Luo JM, Wang M*Effects of HP-β-CD on growth and morphology of Absidia coerulea. World Journal of Microbiology and Biotechnology, 2012, 28(8):2723-2729.

[26] Shen YB, Wang M*, Zhang LT , Ma YH, Ma B , Zheng Y , Liu H, Luo JM. Effects of hydroxypropyl-β-cyclodextrin on cell growth, activity, and integrity of steroid-transforming Arthrobacter simplex and Mycobacterium sp. Applied Microbiology and Biotechnology, 2011,90(6): 1995-2003.

 

获奖情况:

优良果醋饮料发酵菌种选育及发酵关键技术研究与应用,获2015年度天津市科学技术进步奖一等奖。


联系方式

办公地点:天津经济技术开发区第十三大街29号天津科技大学生物工程学院,

邮政编码:300457

办公电话:022-60601256

真:022-60602298

Email: shenyb@tust.edu.cn

 

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