天津科技大学生物工程学院欢迎您!
讲师

王凤华.jpg 

王凤华,博士,天津科技大学生物工程学院讲师。20197月毕业于天津大学,获理学博士学位;20184月至201810月赴耶鲁大学交流访问。

主讲课程

本科生:微生物学、微生物学实验

研究生:结构生物学

科研领域及方向

[1] 食品功能因子的生物合成

[2] 酶的结构与功能解析

[3] 酶的理性设计及定向进化

科研项目情况

[1] 国家自然科学基金青年项目:大蒜黄素单加氧酶催化合成蒜氨酸的分子机制研究及其催化性能调控,2022-2024,主持

[2] 天津市企业科技特派员项目:新型β-木糖苷酶的功能进化及高效制备研究,2021-2022,主持

[3] 国家重点研发计划项目课题:医药与食品工业酶的高效发掘与酶库创建,2021-2024,参与

[4] 天津市合成生物技术创新能力提升行动项目:羟基化氨基酸高效生物合成关键技术开发,2021-2023,参与

[5] 天津市应用基础与前沿技术研究计划:稀少糖转化酶D-阿洛酮糖3-差向异构酶的高通量筛选与定向改造,2019-2022,参与

[6] 国家自然科学基金面上项目:双功能聚对苯二甲酸乙二醇(PET)降解酶的构建、工作机制与应用研究,2020-2023,参与

主要学术成果

先后发表各类科研论文16篇,申请发明专利3项。发表的主要学术论文有:

[1] Fenghua Wang#, Menglu Zhu#, Zhan Song, Chao Li, Yuying Wang, Zhangliang Zhu, Dengyue Sun, Fuping Lu*, Hui-Min Qin*. Reshaping the binding pocket of lysine hydroxylase for enhanced activity, ACS Catalysis, 2020, 10(23): 13946-13956

[2] Fenghua Wang#, Ying Wang#, Luying Jiang, Wenqian Wang, Jingcheng Sang, Xinyu Wang, Fuping Lu and Fufeng Liu*. The food additive fast green FCF inhibits α-synuclein aggregation, disassembles mature fibrils and protects against amyloid-induced neurotoxicity, Food & Function, 2021, 12(12): 5465-5477

[3] Fenghua Wang#, Zehua Xu#, Chen Wang, Zehui Guo, Zhaoting Yuan, Hongwei Kang, Jingwen Li, Fuping Lu*, Yihan Liu*. Biochemical characterization of a tyrosinase from Bacillus aryabhattai and its application, International Journal of Biological Macromolecules, 2021, 176: 37-46

[4] Fenghua Wang#, Cheng Chen#, Kailin Yang#, Yang Xu, Xiaomei Liu, Fan Gao, He Liu, Xia Chen, Qi Zhao, Xiang Liu, Yan Cai*, Haitao Yang*. Michael acceptor-based peptidomimetic inhibitor of main protease from porcine epidemic diarrhea virus, Journal of Medicinal Chemistry, 2017, 60(7): 3212-3216

[5] Fenghua Wang#, Cheng Chen#, Xuemeng Liu, Kailin Yang, Xiaoling Xu*, Haitao Yang*. Crystal structure of feline infectious peritonitis virus main protease in complex with synergetic dual inhibitors, Journal of Virology, 2016, 90(4): 1910-1917

[6] Fenghua Wang#, Cheng Chen#, Wenjie Tan, Kailin Yang*, Haitao Yang*, Structure of main protease from human coronavirus NL63: insights for wide spectrum anti-coronavirus drug design, Scientific Reports, 2016, 6: 22677

[7] Fenghua Wang#, Yusheng Tan#, Huiyan Li, Xia Chen, Jinshan Wang, Shuang Li, Sheng Fu, Qi Zhao, Cheng Chen*, Dan Su*, Haitao Yang, Crystallization and preliminary crystallographic study of human coronavirus NL63 main protease in complex with an inhibitor, Acta Crystallographica Section F-Structural Biology Communications, 2014, 70(8): 1068-1071

[8] Han Zhou#, Fenghua Wang#, Haofeng Wang #, Cheng Chen, Tianqing Zhang, Xu Han, Deping Wang, Chen Chen, Chen Wu, Wei Xie, Zefang Wang, Lei Zhang, Lanfeng Wang*, Haitao Yang*, The conformational changes of Zika virus methyltransferase upon converting SAM to SAH[J]. Oncotarget, 2017, 8(9): 14830-14834

[9] Jinshan Wang#, Fenghua Wang#, Yusheng Tan, Xia Chen, Qi Zhao, Sheng Fu, Shuang Li*, Cheng Chen*, Haitao Yang, Crystallization and preliminary crystallographic study of feline infectious peritonitis virus main protease in complex with an inhibitor[J]. Acta Crystallographica Section F-Structural Biology Communications, 2014, 70(12): 1612-1615

[10] Yusheng Tan#, Fenghua Wang#, Xia Chen, Jinshan Wang, Qi Zhao, Shuang Li, Zefang Wang, Sheng Fu*, Cheng Chen*, Haitao Yang, Crystallization and preliminary crystallographic study of porcine epidemic diarrhea virus main protease in complex with an inhibitor[J]. Acta Crystallographica Section F-Structural Biology Communications, 2014, 70(12): 1608-1611

联系方式

办公地点:天津经济技术开发区第十三大街29号天津科技大学生物工程学院

邮政编码:300457

Emailwangfh@tust.edu.cn