周云雷，博士，毕业于北京师范大学，硕士生导师。Journal of Analysis and Testing期刊优秀青年编委。中国化学会会员，中国生物工程学会会员。2016-2017年新加坡南洋理工生物学院访学学者。国际著名期刊Biosensors and Bioelectronics、Advanced Functional Materials、 Analytical Chemistry、Coordination Chemistry Reviews等期刊审稿人。
主讲课程
本科生：《药物分析》、《药物分析与实验》、《药物分析实验》
研究生：《高等生物化学》
主要教学研究及成果情况
先后主持教改项目1项，发表教改论文3篇，参编教材一部。
[1] 2022年教育部产学合作协同育人项目：交叉学科化学生物学课程教学改革与实践,2022-2023,主持.
[2] 周云雷,殷焕顺,付蕾等.高等农业院校生物无机化学课程开设的思考.广州化工,2019,47(21),138-139.
[3] 国家级大学生创新创业训练计划项目指导教师,2022.
[4] 全国高等农业院校“十三五”规划教材,基础化学实验,参编.
科研领域及方向
[1]生物光电化分析
[2]药物质量监控
[3]食品安全分析
科研项目情况
[1] 国家自然科学基金项目面上：土壤中镉-全氟化合物复合污染体系对小麦生态毒理效应的光电化学研究，2021.01-2024.12,主持.
[2] 国家自然科学基金项目青年：水环境中抗生素对水稻生态毒理效应的光电化学研究，2019.01-2021.12，主持.
[3] 山东省自然科学基金项目面上：微塑料与有机磷酸酯对水稻mRNA胞嘧啶乙酰化影响的OPECT传感研究，2025.01-2027.12，主持.
[4] 山东省自然科学基金项目面上：植物激素调控水稻基因组DNA羟甲基化的光电化学研究，2018.03-2021.06，主持.
[5] 山东省自然科学基金项目青年：循环microRNA 的光电化学检测及其在胃癌早期诊断中的应用研究，2015.01-2017.12，主持.
主要学术成果
以第一或通讯作者先后发表SCI科研论文98篇，授权发明专利15项。近5年发表的主要学术论文有：
[1] Zhidong Yin, Yunlei Zhou*, Yixin Hu, Xingyu Liu, Xueyan Li, Desong Zhu, Huanshun Yin*, Construction of dual-mode photoelectrochemical-colorimetric biosensor for N4-acetylcytidine (ac4C) detection based on Bi2O2S/Bi4O5Br2/CeO2 type-II/Z-Scheme tandem heterojunction, Sensors and Actuators B: Chemical, 2026, 447, 138772.
[2] Zhidong Yin, Huanshun Yin*, Yunlei Zhou*, Hongda Liu, CRISPR/Cas13a-mediated photoelectrochemical-colorimetric dual-mode biosensor for RNA N-acetyltransferase 10 detection based on Bi2O2S/Ag2S and laccase-like nanozyme, Biosensors and Bioelectronics, 2026, 295, 118298.
[3] Xingyu Liu, Yunlei Zhou*, Huanshun Yin*, Xueyan Li, Junling Duan, Synergistic application of PEC-OPECT-CL multimodal biosensing and photocatalytic sterilization based on hollow tubular Bi12O17Cl2/In2O3 Z-scheme heterojunction for Vibrio parahaemolyticus, Journal of Hazardous Materials, 2026, 501, 140831.
[4] Xingyu Liu, Yunlei Zhou*, Huanshun Yin*, Xueyan Li, Yixin Hu, Zhidong Yin, Junling Duan, A portable nanozyme-integrated photoelectrochemical and colorimetric dual-mode biosensor for E. coli O157:H7 detection in milk, Talanta, 2026, 298, 128859.
[5] Xueyan Li, Yunlei Zhou*, Huanshun Yin*, Xingyu Liu, Peng Ju, Desong Zhu, Chao Xu, A domino effect in sensing: Cascade amplification on a heterojunction photoelectrode for ultrasensitive detection of okadaic acid with photocurrent polarity switching, Sensors and Actuators B: Chemical, 2026, 450, 139271.
[6] Shuqi Gong, Yunlei Zhou*, Huanshun Yin*, Tianyi Sun, Chengji Sui, Oxygen vacancy modulating the ·OH yield of Bi4O5Br2 for improving the photocatalytic inactivation of Methicillin‐Resistant Staphylococcus Aureus, Small, 2026, 22, e12058.
[7] Yunlei. Zhou, Huanshun. Yin*, Recent advances in photoelectrochemical biosensors for detection of mycotoxins and marine biotoxins in food: identification and signal amplification strategy, Journal of Agricultural and Food Chemistry, 2025, 73, 18561-18584.
[8] Yunlei Zhou, Xiaoting Cui, Yulin Zheng, Tiantong Jiang, Wenjuan Sun, Huanshun Yin*, Construction of bifunctional Se-MoSe2-Cu2MoS4 Z-scheme heterojunction: Its application in photoelectrochemical biosensing and photocatalytic degradation, Chemical Engineering Journal, 2025, 507, 160549.
[9] Miao Zhang, Yunlei Zhou*, Haowei Zhang, Huanshun Yin*, Z-Scheme heterostructure synergistic oxygen vacancy defect engineering: Realizing ALKBH5 based on organic photoelectrochemical transistor bioanalysis, Chemical Engineering Journal, 2025, 522, 167702.
[10] Haowei. Zhang, Yunlei. Zhou*, Miao. Zhang, Huanshun. Yin*, Yixin. Hu, Zzhidong. Yin, Shiyun. Ai, Construction of CdIn2S4/MXene-TiO2 Z-Scheme heterojunction for high-gain organic photoelectrochemical transistor to achieve maximized transconductance at zero bias, Small, 2025, 21, e2408470.
[11] Zhengkun Yu, Yunlei Zhou*, Xingyu Liu, Shuqi Gong, Tianyi Sun, Huanshun Yin*, Jingting Kang, In3+-doped Bi/BiOCl/Bi(In3+)-MOF composite for accelerating photocatalytic elimination of antibiotic-resistant bacteria and genes under co-effect of nanoconfinement and reactive oxygen species, Separation and Purification Technology, 2025, 361, 131318.
[12] Zhengkun Yu, Yunlei Zhou*, Shuqi Gong, Tianyi Sun, Xingyu Liu, Xueyan Li, Huanshun Yin*, Pengfei Wang*, (Bi, Ni)‐based bimetallic MOF with light‐assisted hydrogen peroxide generation for synergistic and efficient photocatalytic antimicrobial, Advanced Healthcare Materials, 2025, 15,
[13] Huanshun Yin, Yunlei Zhou*, Chengji Sui*, Jia Ding, Jun Wang*, Recent advances on photocatalytic degradation of phthalate ester plasticizers using nanomaterial photocatalysts, Environmental Research, 2025, 276, 121497.
[14] Tianyi Sun, Yunlei Zhou*, Huanshun Yin*, Shuqi Gong, Zhengkun Yu, Hanyu Liu, Jiating Cheng, Jun Wang*, Modulation of Bi4O5I2 energy band with oxygen vacancy defect engineering to optimize hydroxyl radical generation for photocatalytic sterilization, Chemical Engineering Journal, 2025, 522, 167950.
[15] Yixin Hu, Yunlei Zhou*, Huanshun Yin*, Zhidong Yin, Tengjin Wang, Xingyu Liu, Xueyan Li, Zhe Chi*, Dual‐mode detection of RNA demethylation protein ALKBH3 using a two‐legged DNA‐Walker‐mediated BiOI/In2O3‐gated organic photoelectrochemical transistor biosensor, Small, 2025, 21,
[16] Yixin Hu, Yunlei Zhou*, Huanshun Yin*, Zhidong Yin, Qing Li, Xingyu Liu, Xueyan Li, Zr‐MOF mediated gate polarity switching in organic photoelectrochemical transistor‐photoelectrochemical‐colorimetric three‐Mode biosensor for m6A RNA detection, Advanced Functional Materials, 2025, 36, e15488.
[17] Shuqi Gong, Rongyu Zhang, Chengji Sui, Yunlei Zhou*, Zhengkun Yu, Li Ma, Huanshun Yin, Tianyi Sun, Junling Duan*, One-pot hydrothermal preparation of Bi/Bi2O2CO3 with improved photocatalytic activity for bisphenol A degradation, Journal of Environmental Chemical Engineering, 2025, 13, 115062.
[18] LuLu Cao, Xianqiang Gao, Yunlei Zhou*, Shugang Zhang, Miao Zhang, Huanshun Yin*, Oxygen vacancy and Z-Scheme BiOIO3@Bi4O5Br2 heterojunction cooperate to enhance the sensitivity of photoelectrochemical biosensors for the detection of DNA demethylase MBD2, Chemical Engineering Journal, 2025, 517, 164277.
[19] Miao Zhang, Yunlei Zhou*, Haowei Zhang, Huanshun Yin*, Zhengkun Yu, Zhidong Yin, Ying Tian, Minghui Wang, Shiyun Ai, Reaction-mediated dual signaling inhibition gated organic photoelectrochemical transistors biosensor for FTO activity detection based on the in situ oxidization of ZnSe/Bi2MoO6 heterojunction, Chemical Engineering Journal, 2024, 483, 149118.
[20] Miao Zhang, Yunlei Zhou*, Haowei Zhang, Huanshun Yin*, Jingrui Duan, Shiyun Ai, Cu2O-mediated heterojunction conversion from dual type II to dual Z-Scheme: its application in photoelectric–colorimetric dual-mode detection of fat mass and obesity-associated (FTO) protein, Analytical Chemistry, 2024, 96, 16080-16090.
[21] Miao Zhang, Haowei Zhang, Yunlei Zhou*, Huanshun Yin*, Zhengkun Yu, Xinyue Zhang, Shiyun Ai, Minghui Wang, Enzymatically mediated in situ generation of Z-Scheme Bi2S3/Bi2MoO6 heterojunction-based organic photoelectrochemical transistor for METTL3/METTL14 detection, Analytical Chemistry, 2024, 96, 13086-13095.
[22] Haowei Zhang, Yunlei Zhou*, Miao Zhang, Yaoyuan Cao, Huanshun Yin*, Shiyun Ai, In2S3/MXene‐gated organic photoelectrochemical transistor with target‐induced dipedal DNA Walker modulation for DBP biosensing, Advanced Functional Materials, 2024, 34,
[23] Haowei Zhang, Miao Zhang, Yunlei Zhou*, Zhen Qiao, Lanlan Gao, Lulu Cao, Huanshun Yin*, Minghui Wang, Organic photoelectrochemical transistor aptasensor for dual-mode detection of DEHP with CRISPR-Cas13a assisted signal amplification, Journal of Hazardous Materials, 2024, 470, 134175.
[24] Haowei Zhang, Miao Zhang, Zhengkun Yu, Yunlei Zhou*, Yixin Hu, Lanlan Gao, Lulu Cao, Huanshun Yin*, Shiyun Ai, MXene-enhanced Bi2S3/CdIn2S4 heterojunction photosensitive gate for DEHP detection in a signal-On OPECT aptamer biosensor, Analytical Chemistry, 2024, 96, 1948-1956.
[25] Zhengkun Yu, Yunlei Zhou*, Haowei Zhang, Miao Zhang, Shuqi Gong, Huanshun Yin*, Tianyi Sun, Oxygen vacancy-rich β-Bi2O3/Bi2O2SiO3 Z-Scheme heterojunction: A strategy to enhance visible light-driven photocatalytic removal of ARB and ARGs, Environmental Pollution, 2024, 358, 124500.
[26] Lanlan Gao, Yunlei Zhou*, Lulu Cao, Yaoyuan Cao, Haowei Zhang, Miao Zhang, Huanshun Yin, Shiyun Ai, Photoelectrochemical sensor for histone deacetylase Sirt1 detection based on Z-scheme heterojunction of CuS-BiVO4 photoactive material and the cyclic etching of MnO2 by NADH, Talanta, 2024, 268, 125307.
[27] Lanlan Gao, Haowei Zhang, Yunlei Zhou*, Huanshun Yin, Lulu Cao, Zhenyong Hu, Miao Zhang, Shiyun Ai, Organic photoelectrochemical transistor biosensor for the detection of histone deacetylase Sirt1 based on the cleavage of deacetylated peptide chain by recombinant lysine endopeptidase, Sensors and Actuators B: Chemical, 2024, 417, 136144.
[28] Lanlan Gao, Hong Wang, Yunlei Zhou*, Zhipeng Tian, Huanshun Yin, Jun Wang, Preparation of Ti3C2Tx-based MXene composite aerogel and its adsorption performance for dibutyl phthalate, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2024, 686, 133452.
[29] Lulu. Cao, Yunlei. Zhou*, Lanlan. Gao, Huanshun. Yin*, Miao. Zhang, Haowei. Zhang, Peng. Ju, Kunpeng. Dou, Shiyun. Ai, Ascorbic acid induced the improved oxygen vacancy defects of Bi4O5Br2 and its application on photoelectrochemical detection of DNA demethylase MBD2 with improved detection sensitivity, Small, 2024, 20, e2306365.
[30] Yunlei Zhou, Huanshun Yin*, Shiyun Ai, Recent advances and applications of Bi2S3-based composites in photoelectrochemical sensors and biosensors, TrAC Trends in Analytical Chemistry, 2023, 158, 116876.
[31] Yunlei Zhou, Zhuangzhuang Wang, Huanshun Yin*, Xiaoting Cui, Ying Tian, Zhen Qiao, Suo Wang, Runye Hu, Wenjing Lv, An Mao*, Jun Wang, One-pot synthesis of 2D Ag/BiOCl/Bi2O2CO3 S-scheme heterojunction with oxygen vacancy for photocatalytic disinfection of Fusarium graminearum in vitro and in vivo, Chemosphere, 2023, 331, 138768.
[32] Yulin Zheng, Xiaoting Cui, Huanshun Yin*, Haowei Zhang, Lulu Cao, Lanlan Gao, Yunlei Zhou*, Peng Ju*, Shiyun Ai, Antibody-free photoelectrochemical biosensor for DNA carboxylation detection based on SnS2@Ti3C2 heterojunction, Analytica Chimica Acta, 2023, 1251, 341011.
[33] Zhengkun Yu, Yunlei Zhou*, Haowei Zhang, Miao Zhang, Rongyu Zhang, Huanshun Yin*, Jun Wang*, One-pot hydrothermal preparation of rich-oxygen vacant Bi2SiO5/CuBi2O4 Z-Scheme heterojunction for visible light-driven photocatalytic removal of antibiotic-resistant bacteria, Chemical Engineering Journal, 2023, 478, 147353.
[34] Suo Wang, Huanshun Yin*, Jia Ding, Haodong Chen, Lingsong Wang, Yunlei Zhou*, Kexue Liu, Jun Wang*, One-pot preparation of novel Bi/BiOBr/Bi2O2CO3 heterojunction for pollutant degradation under visible light: Catalyst generation insights, reaction mechanism, degradation pathways, and toxicological effects, Surfaces and Interfaces, 2023, 37, 102642.
[35] Lanlan Gao, Yunlei Zhou*, Lulu Cao, Zhenyong Hu, Xinyue Mao, Haowei Zhang, Miao Zhang, Huanshun Yin*, Shiyun Ai, NAD+ mediated photoelectrochemical biosensor for histone deacetylase Sirt1 detection based on CuO-BiVO4-AgNCs heterojunction and hybridization chain reaction amplification, Analytica Chimica Acta, 2023, 1284, 341989.
[36] Xiaoting Cui, Yulin Zheng, Yunlei Zhou*, Tiantong Jiang, Suo Wang, Lulu Cao, Lanlan Gao, Huanshun Yin*, Shiyun Ai, Antibody-free photoelectrochemical strategy for simultaneous detection of methylated RNA, METTL3/METTL14 protein and MazF protein based on enhanced photoactivity of MoSe2–BiOI nanocomposite, Biosensors and Bioelectronics, 2023, 222, 115015.
[37] LuLu Cao, Yunlei Zhou*, Lanlan Gao, Yulin Zheng, Xiaoting Cui, Huanshun Yin*, Suo Wang, Miao Zhang, Haowei Zhang, Shiyun Ai, Photoelectrochemical biosensor for DNA demethylase detection based on enzymatically induced double-stranded DNA digestion by endonuclease-exonuclease system and Bi4O5Br2–Au/CdS photoactive material, Talanta, 2023, 262, 124670.
[38] Lulu Cao, Hong Wang, Kun Peng, Yunlei Zhou*, Lanlan Gao, Hao Liu, Zhipeng Tian, Huanshun Yin, Strong adsorption and high stability of the thin-layered MXene adsorbent: Simple synthesis and application to reduce the toxicity of wastewater towards mung beans, Surfaces and Interfaces, 2023, 41, 103172.
[39] Yulin Zheng, Yunlei Zhou*, Xiaoting Cui, Huanshun Yin*, Shiyun Ai, Enhanced photoactivity of CdS nanorods by MXene and ZnSnO3: Application in photoelectrochemical biosensor for the effect of environmental pollutants on DNA hydroxymethylation in wheat tissues, Materials Today Chemistry, 2022, 24, 100878.
[40] Yulin Zheng, Yunlei Zhou*, Xiaoting Cui, Hengming Yan, Lulu Cao, Lanlan Gao, Huanshun Yin*, Investigation of the effect of antibiotics on 5-formylcytosine content in mazie seedling tissues based on photoelectrochemical biosensor, Journal of Hazardous Materials, 2022, 436, 129146.
[41] Yulin Zheng, Xi Fang, Yunlei Zhou*, Xiaoting Cui, Lulu Cao, Lanlan Gao, Huanshun Yin, Jun Wang*, Shiyun Ai, Enhanced photoactivity of Bi2S3 nanoflowers by CS-AgBr and CeO2: Application in photoelectrochemical biosensor for the effect of antibiotics on N6-methyladenosine in rice tissues, Journal of Electroanalytical Chemistry, 2022, 920, 116640.
[42] Yulin Zheng, Xiaoting Cui, Yunlei Zhou*, Haowei Zhang, Lulu Cao, Lanlan Gao, Huanshun Yin*, Shiyun Ai, MXene enhanced photoactivity of Bi2O3/Bi2S3 heterojunction with G-wire superstructure for photoelectrochemical detection of TET1 protein, ACS Sensors, 2022, 7, 3116-3125.
[43] Suo Wang, Huanshun Yin*, Penghui Li, Jia Ding, Lingsong Wang, Yunlei Zhou*, Jun Wang*, Controlled preparation of Bi/BiOCl with enhanced catalytic activity for organic pollutant under visible light using one-pot hydrothermal technology, Chemosphere, 2022, 307, 136188.
[44] Lanlan Gao, Yunlei Zhou*, Lulu Cao, Xiaoting Cui, Yulin Zheng, Huanshun Yin*, Shiyun Ai, Photoelectrochemical biosensor for histone deacetylase Sirt1 detection based on polyaspartic acid-engaged and triggered redox cycling amplification and enhanced photoactivity of BiVO4 by Gold nanoparticles and SnS2, Analytical Chemistry, 2022, 94, 16936-16944.
[45] Jia Ding, Lanlan Gao, Lulu Cao, Yunlei Zhou*, Hao Wang, Jingrui Duan, Huanshun Yin*, Jianchao Sun*, Shiyun Ai, Photoelectrochemical immunosensor for DNA hydroxymethylation based on PTCA-sensitized perovskite Bi4TaO8Cl, Sensors and Actuators B: Chemical, 2022, 355, 131290.
[46] Xiaoting Cui, Yunlei Zhou*, Yulin Zheng, Yixin Hu, Zhuangzhuang Wang, Lanlan Gao, Lulu Cao, Huanshun Yin*, Shiyun Ai, Investigation the effect of antibiotics on the content of N6-methyladenosine in rice seedling tissue and heavy metal on FTO activity based on antibody-free photoelectrochemcial biosensor, Sensors and Actuators B: Chemical, 2022, 364, 131896.
[47] Xiaoting Cui, Xi Fang, Yunlei Zhou*, Ziqi Ren, Lianxiang Wei, Yulin Zheng, Huanshun Yin, Jun Wang, Shiyun Ai, Photoelectrochemical immunosensor for RNA methylation detection based on the enhanced photoactivity of Bi2S3 nanorods by g-C3N4 nanosheets, Microchemical Journal, 2022, 183, 108031.
[48] Yunlei Zhou, Huanshun Yin*, Shiyun Ai, Applications of two-dimensional layered nanomaterials in photoelectrochemical sensors: A comprehensive review, Coordination Chemistry Reviews, 2021, 447, 214156.
[49] Jia Ding, Yunlei Zhou*, Qian Wang, Shiyun Ai, Photoelectrochemical biosensor for DNA hydroxymethylation detection based on the enhanced photoactivity of in-situ synthesized Bi4NbO8Cl@Bi2S3 heterojunction, Biosensors and Bioelectronics, 2021, 194, 113580.
[50] Jia Ding, Fei Liu, Chunling Qi, Yunlei Zhou*, Huanshun Yin*, Shiyun Ai, Enhanced photoactivity of perovskite Bi4NbO8Cl/PTC-NH2 heterojunction and its application for photoelectrochemical sensing of DNA hydroxymethylation, Sensors and Actuators B: Chemical, 2021, 344, 130211.
[51] Yunlei Zhou, Huanshun Yin*, Wei-Wei Zhao*, Shiyun Ai, Electrochemical, electrochemiluminescent and photoelectrochemical bioanalysis of epigenetic modifiers: A comprehensive review, Coordination Chemistry Reviews, 2020, 424, 213519.
授权发明专利主要有：
[1]周云雷，崔晓婷等，一种无抗体酶辅助的光电化学传感器用于检测m6A的方法，ZL202111441681.1
[2]周云雷，王壮壮等，一种Ag-Bi复合纳米光催化杀菌剂材料及其制备方法，ZL202111207715.0
[3]殷焕顺，周云雷等，一种检测氨苄青霉素的电化学生物传感器及其制备方法，ZL201810417263.0
获奖情况
研究成果分别获得山东省化学化工学会自然科学奖一等奖与山东省高等学校自然科学奖二等奖。先后荣获山东优秀本科生论文指导教师、山东省优秀硕士论文指导教师、山东省化学化工学会优秀科技工作者、山东省研究生创新成果奖三等奖指导教师。独立指导5位研究生获国家奖学金。
联系方式
办公地点：天津经济技术开发区第十三大街29号天津科技大学生物工程学院
邮政编码：300457
办公电话：022-60601104
传 真：022-60602298
Email： 97974091@tust.edu.cn
