王凤华，博士，天津科技大学生物工程学院副教授，硕士生导师。2019年7月毕业于天津大学，获理学博士学位；2018年4月至2018年10月赴耶鲁大学交流访问。天津市科技特派员，院教代会代表，《食品研究与开发》第二届青年编委，《天津科技大学学报》青年编委。
主讲课程：
本科生：微生物学、微生物学实验
研究生：结构生物学
科研领域及方向
[1] 食品功能因子的生物合成
[2] 酶的结构与功能解析
[3] 酶的理性设计及定向进化
科研项目情况
[1] 国家自然科学基金面上项目：脱氧蒜氨酸生物合成途径中双酶偶联协同催化调控机制研究，2026-2029，主持
[2] 国家重点研发计划项目：功能性维生素绿色生物制造关键技术研究，2023-2027，子课题负责人
[3] 国家自然科学基金青年项目：大蒜黄素单加氧酶催化合成蒜氨酸的分子机制研究及其催化性能调控，2022-2024，主持
[4] 天津市应用基础研究青年项目：高活力粟酒裂殖酵母黄素单加氧酶构效关系和分子进化的研究，2022-2024，主持
[5] 天津市企业科技特派员项目：新型β-木糖苷酶的功能进化及高效制备研究，2021-2022，主持
[6] 工业发酵微生物教育部重点实验室暨天津市工业微生物重点实验室开放课题：蒜氨酸酶的分子进化及高效制备研究，2023-2024，合作主持
[7] 国家重点研发计划项目：医药与食品工业酶的高效发掘与酶库创建，2021-2024，参与
[8] 国家自然科学基金面上项目：基于多结构域特征的磷脂酶定向合成稀有磷脂的构效关系解析及性能调控研究，2022-2024，参与
[9] 天津市合成生物技术创新能力提升行动项目：羟基化氨基酸高效生物合成关键技术开发，2021-2023，参与
[10] 天津市应用基础与前沿技术研究计划：稀少糖转化酶D-阿洛酮糖3-差向异构酶的高通量筛选与定向改造，2019-2022，参与
主要学术成果
先后发表各类科研论文30余篇，授权发明专利6项，申请发明专利9项。代表性学术论文：
[1] Gang Zhu#, Chenchen Zhang#, Yunjie Xiao#, Enhua Tian, Zhaolin Song, Yuying Gao, Qinggang Li, Yu Li, Fuping Lu*, Yihan Liu*, Fenghua Wang*. Highly efficient one-pot multienzyme cascades for the synthesis of S-allyl-L-cysteine from L-serine and allyl mercaptan, Journal of Agricultural and Food Chemistry, 2025, 73(26):16505-16514.
[2] Chenchen Zhang#, Wenjing Gao#, Zhaolin Song#, Mengjun Dong, Huixin Lin, Gang Zhu, Mengka Lian, Yunjie Xiao, Fuping Lu*, Fenghua Wang*, Yihan Liu*. Computation-aided phylogeny-oriented engineering of β-xylosidase: Modification of "blades" to enhance stability and activity for the bioconversion of hemicellulose to produce xylose. Journal of Agricultural and Food Chemistry, 2024, 72(5):2678-2688
[3] Enping Guo#, Lei Zhao#, Ziyuan Li, Lei Chen, Jingwen Li, Fuping Lu, Fenghua Wang*, Kui Lu*, Yihan Liu*. Biodegradation of bisphenol A by a Pichia pastoris whole-cell biocatalyst with overexpression of laccase from Bacillus pumilus and investigation of its potential degradation pathways, Journal of Hazardous Materials, 2024, 474:134779
[4]Fenghua Wang, Hongbin Qi, Huimin Li, Xuanzhen Ma, Xin Gao, Chao Li, Fuping Lu*, Shuhong Mao* & Hui-Min Qin*. State-of-the-art strategies and research advances for the biosynthesis of D-amino acids. Critical Reviews in Biotechnology, 2024, 44(4): 495-513
[5] Meijing Wei, Xin Gao, Wei Zhang, Chao Li, Fuping Lu, Lijun Guan, Weidong Liu, Jianwen Wang, Fenghua Wang*, Hui-Min Qin*. Enhanced thermostability of an L-rhamnose isomerase for D-allose synthesis by computation-based rational redesign of flexible regions, Journal of Agricultural and Food Chemistry, 2023, 71(42): 15713-15722
[6] Fenghua Wang#, Xiangyang Ma#, Ying Sun, Enping Guo, Chaoshuo Shi, Zhaoting Yuan, Yu Li, Qinggang Li*, Fuping Lu*, Yihan Liu*. Structure-guided engineering of a protease to improve its activity under cold conditions, Journal of Agricultural and Food Chemistry, 2023, 71(33): 12528-12537
[7] Fenghua Wang#, Menglu Zhu#, Zhan Song, Chao Li, Yuying Wang, Zhangliang Zhu, Dengyue Sun, Fuping Lu*, Hui-Min Qin*. Reshaping the binding pocket of lysine hydroxylase for enhanced activity, ACS Catalysis, 2020, 10(23): 13946-13956
[8] Fenghua Wang#, Zehui Guo#, Zixuan Yang, Xueying Li, Xue Zhang, Xiangyang Ma, Zhuoxuan Han, Fuping Lu*, Yihan Liu*. Utilization of soybean oil waste for a high-Level production of ceramide by a novel phospholipase C as an environmentally friendly process, Journal of Agricultural and Food Chemistry, 2022, 70(10): 3228-3238
[9] Fenghua Wang#, Zehua Xu#, Chen Wang, Zehui Guo, Zhaoting Yuan, Hongwei Kang, Jingwen Li, Fuping Lu*, Yihan Liu*. Biochemical characterization of a tyrosinase from Bacillus aryabhattai and its application, International Journal of Biological Macromolecules, 2021, 176: 37-46
[10] Fenghua Wang#, Ying Wang#, Luying Jiang, Wenqian Wang, Jingcheng Sang, Xinyu Wang, Fuping Lu and Fufeng Liu*. The food additive fast green FCF inhibits α-synuclein aggregation, disassembles mature fibrils and protects against amyloid-induced neurotoxicity, Food & Function, 2021, 12(12): 5465-5477
[11] Fenghua Wang#, Xiuqi Ge#, Zhaoting Yuan, Xue Zhang, Xiuxiu Chu, Fuping Lu*, Yihan Liu*. Insights into the mechanism for the high-alkaline activity of a novel GH43 β-xylosidase from Bacillus clausii with a promising application to produce xylose, Bioorganic Chemistry, 2022, 126: 105887
[12] Fenghua Wang, Zhiming Yao, Xue Zhang, Zhuoxuan Han, Xiuxiu Chu, Xiuqi Ge, Fuping Lu*, Yihan Liu*. High-level production of xylose from agricultural wastes using GH11 endo-xylanase and GH43 β-xylosidase from Bacillus sp. Bioprocess and Biosystems Engineering, 2022, 45: 1705-1717
[13] Fenghua Wang#, Cheng Chen#, Kailin Yang#, Yang Xu, Xiaomei Liu, Fan Gao, He Liu, Xia Chen, Qi Zhao, Xiang Liu, Yan Cai*, Haitao Yang*. Michael acceptor-based peptidomimetic inhibitor of main protease from porcine epidemic diarrhea virus, Journal of Medicinal Chemistry, 2017, 60(7): 3212-3216
[14] Fenghua Wang#, Cheng Chen#, Xuemeng Liu, Kailin Yang, Xiaoling Xu*, Haitao Yang*. Crystal structure of feline infectious peritonitis virus main protease in complex with synergetic dual inhibitors, Journal of Virology, 2016, 90(4): 1910-1917
[15] Fenghua Wang#, Cheng Chen#, Wenjie Tan, Kailin Yang*, Haitao Yang*, Structure of main protease from human coronavirus NL63: insights for wide spectrum anti-coronavirus drug design, Scientific Reports, 2016, 6: 22677
代表性专利：
[1] 一种黄素单加氧酶突变体及其制备和应用，ZL202111516213.6
[2] 一种酶活力提高的黄素单加氧酶突变体及其应用，202410341833.8
[3] 一种甲硫氨酸γ-裂解酶突变体及其应用，202511430419.5．
[4] 一种脂肪酶突变体及其在合成维生素A棕榈酸酯中的应用，202511241309.4．
[5] 一种新型β-木糖苷酶及其制备，ZL202011029392.6．
[6] 一种耐热木糖苷酶突变体及其制备，ZL202210992314.9．
[7] 一种酪氨酸酶及其制备与应用，ZL202111068005.4．
联系方式
办公地点：天津经济技术开发区第十三大街29号天津科技大学生物工程学院
邮政编码：300457
Email：wangfh@tust.edu.cn
