孙雪，博士，毕业于中国科学院大学。天津科技大学生物工程学院副教授，硕士生导师。

主讲课程

本科生：《微生物学实验》

研究生：《专业综合实验》、《实验原理与技术》

科研领域及方向

[1] 工业菌种设计构建与智能化高通量筛选

[2] 食品功能因子基因工程菌种的构建

科研项目情况

[1] 国家重点研发计划子课题：母乳寡糖高效合成细胞工厂构筑与优化，2024-2029，主持。

[2] 中国博士后科学基金第73批面上资助：大肠杆菌乳糖生物传感器的构建优化及机制探究，2023-2024，主持。

[3] 国家自然科学基金面上项目：基于全细胞生物传感器的2′-岩藻糖基乳糖生产菌种高通量筛选方法开发及高产机制解析，2025-2028，参与。

[4] 国家自然基金面上项目：以异亮氨酰-tRNA合成酶为例构建一类新型氨基酸生物传感器，2019-2022，参与。

主要学术成果

先后发表高水平SCI论文7篇，授权发明专利1项。发表的主要学术论文有：

[1] Junzhong Li, Tingyu He, Shaodong Ren, Daoshuai Huang, Jinhuai He, Xue Sun*, Yu Li*, Fuping Lu, Qinggang Li*. Construction and optimization of a BgaR-based lactose biosensor for high-throughput selection of human milk oligosaccharide producers. Journal of Agricultural and Food Chemistry, 2025, 73, 17138−17146.

[2] Junzhong Li, Tingyu He, Jiajia Zhao, Yu Pang, Yuanyang Zhang, Yihan Liu, Xue Sun*, Yu Li*, Fuping Lu, Qinggang Li*. Combination of metabolic engineering and high-throughput screening to realize high-producing lacto-N-triose II in Escherichia coli. Journal of Agricultural and Food Chemistry, 2025, 73, 17769−17775.

[3] Li Qinggang*, Liu Chuan, He Jinhuai, Liu Tiantian, Zhang Wencong, Xie Zhenzhen, Zong Jianfei, Li Yu, Sun Xue*, Lu Fuping. Construction and application of 3-fucosyllactose whole-cell biosensor for high-throughput screening of overproducers. Bioresource Technology. 2024, 402, 130798.

[4] Xue Sun; Zetao Peng; Chang Li; Yanling Zheng; Ya'nan Cheng; Jianfei Zong; Fuping Lu; Yu Li; Qinggang Li*. Combinatorial metabolic engineering and tolerance evolving of Escherichia coli for high production of 2'-fucosyllactose, Bioresource Technology, 2023, 372: 128667.

[5] Li Qinggang*, Ren Haojie, Liao Zhenjiang, Xia Shuchang, Xue Sun*. High throughput screening of transcription factor lysG for constructing a better lysine Biosensors. 2024, 14, 455.

[6] Sun, Xue†; Li, Qinggang†; Wang, Yu†; Zhou, Wenjuan; Guo, Yanmei; Chen, Jiuzhou; Zheng, Ping; Sun, Jibin; Ma, Yanhe; Isoleucyl-tRNA synthetase mutant based whole-cell biosensor for high-throughput selection of isoleucine overproducers., Biosensors and Bioelectronics, 2021, 172: 112783.

[7] Taiwo Dele-Osibanjo†, Li Qinggang†, Zhang Xiaoli, Guo Xuan, Feng Jinhui, Liu Jiao, Sun Xue, Wang Xiaowei, Zhou Wenjuan, Zheng Ping, Sun Jibin, MaYanhe. Growth-coupled evolution of phosphoketolase to improve L-glutamate production by Corynebacterium glutamicum. Applied Microbiology and Biotechnology. 2019. 103. 8413–8425.

授权发明专利主要有：

一种RNA聚合酶β亚单位突变体及应用，ZL 2023 1 0064132.X.

联系方式

办公地点：天津经济技术开发区第十三大街29号天津科技大学生物工程学院

邮政编码：300457

传 真：022-60602298

Email：sunxue@tust.edu.cn