赵蕾，博士，毕业于天津科技大学。天津科技大学生物工程学院讲师。

主讲课程

本科生：暂未开课

研究生：暂未开课

主要教学研究及成果情况

无。

科研领域及方向

[1] 酶工程：新酶分子的基因挖掘，酶的结构与功能解析，酶的理性设计与定向进化，酶基因高效表达系统的构建与优化，酶制剂应用技术的开发与拓展

[2] 生物质的转化与高值应用：木质纤维素的酶法修饰与高值化利用，开发生物质基新材料等。

科研项目情况

[1] 国家自然科学基金(青年科学基金项目C类)，漆酶的耐碱性调控机制解析及与裂解多糖单加氧酶协同降解木质素机理研究，在研，主持，2026.01-2028.12。

[2] 宿州市“通济”科技计划项目，木质素降解关键酶分子设计与功能改造技术与应用，在研，主持，2025.10-2028.09.

[3] 横向课题，白酒酒糟酶解资源化技术开发，深圳中农秸美科技股份有限公司，在研，主持，2024.11−2026.10。

主要学术成果

先后发表各类科研论文16篇，授权发明专利6项。发表的主要学术论文有：

[1] Lei Zhao, Dianqing Liu, Yian Cai, Xiangyang Ma, Hui Sun, Jiyan Li, Yingjian Qin, Fuping Lu, Yihan Liu*．Structure-informed engineering of a laccase with enhanced catalytic activity and thermostability for facilitating lignocellulosic biomass saccharification．Bioresource Technology，2026,461:135474.

[2] Lei Zhao, Ailan Huang, Mei Yang, Minglu Zhang, Fei Yu, Fuping Lu,* Xiaohong Chen, Yanfei Wang*, Fufeng Liu*, Engineering laccase from Bacillus pumilus for improved thermostability and its combination with lytic polysaccharide monooxygenase for lignin depolymerization. Journal of Agricultural and Food Chemistry. 2025, 73: 18390−18401.

[3] Lei Zhao1, Xiangyang Ma1, Yunan Ding, Kaixin Zheng, Kefen Wang, Fuping Lu, Yihan Liu*, Engineering a protease K for efficient degradation of wool scale layer using a substrate pocket modification. Fermentation, 2025, 11: 51.

[4] Lei Zhao, Jiayu Zhang, Danyang Zhao, Li Jia, Bo Qin, Xianyuan Cao, Lihua Zang, Fuping Lu*, Fufeng Liu*. Biological degradation of lignin: A critical review on progress and perspectives. Industrial Crops & Products, 2022, 188: 115715.

[5] Lei Zhao, Li Jia, Danyang Zhao, Xianyuan Cao, Na Wang, Fei Yu, Fuping Lu*, Fufeng Liu*. Functional and mechanistic study of a lytic polysaccharide monooxygenase that contributes to xylan degradation by xylanase. ACS Sustainable Chemistry & Engineering. 2022, 10: 13955−13963.

[6] Lei Zhao1, Shuangzhen Guo1, Yuhui Ci, Yajing An, Ailan Huang, Zuyu Li, Yingjian Qin, Qingyang Xu, Fuping Lu, Fufeng Liu*. Efficient saccharification of cellulose by a photo-assisted biocatalysis system. Industrial Crops & Products, 2021, 174: 114191.

[7] Lei Zhao, Jishi Zhang*, Wenqian Zhao, Lihua Zang. Improved fermentative hydrogen production with the addition of calcium-lignosulfonate-derived biochar. Energy Fuels. 2019, 33: 7406−7414.

[8] Enping Guo1, Lei Zhao1, Ziyuan Li, Lei Chen, Jingwen Li, Fuping Lu, Fenghua Wang*, Kui Lu*, Yihan Liu*. Biodegradation of bisphenol A by a Pichia pastoris whole-cell biocatalyst with overexpression of laccase from Bacillus pumilus and investigation of its potential degradation pathways. Journal of Hazardous Materials, 2024, 474: 134779.

[9] Li Jia1, Lei Zhao1, Bo Qin, Fuping Lu, Dingkuo Liu, Fufeng Liu*, Enhancement of rice husks saccharification through hydrolase preparation assisted by lytic polysaccharide monooxygenase. Enzyme and Microbial Technology, 2023, 171: 110319.

[10] Xianyuan Cao1, Lei Zhao1, Weifang Dong, Haoe Mo, Teer Ba, Tianpeng Li, Dan Guan c, Wenqian Zhao, Na Wang, Zhongmin Ma, Lihua Zang*. Revealing the mechanisms of alkali-based magnetic nanosheets enhanced hydrogen production from dark fermentation: Comparison between mesophilic and thermophilic conditions. Bioresource Technology. 2022, 343: 126141.

[12] Xiangyang Ma, Liya Wang, Jingyu Chen, Enping Guo, Hongchen Zheng, Lei Zhao*, Fuping Lu*, Yihan Liu*, Surfactant-tolerance evolution of Bacillus clausii protease for enhancing activity and stability by reshaping the substrate access tunnel. Colloids and Surfaces B: Biointerfaces, 2025, 245: 114289.

[13] 岑铭, 王玉博, 赵蕾, 李佩贤, 崔博雅, 周美怡, 温洋兵, 路福平* 刘夫锋*. LPMO结合硫酸水解制备纤维素纳米晶体. 中国造纸, 2021, 40(11): 53−59.

授权发明专利主要有：

[1] 一种裂解多糖单加氧酶突变体及其基因、工程菌、制备方法与应用, ZL202411148108.5

[2] 一种耐高温漆酶突变体及其制备与应用, ZL202411171011.6.

[3] 一种木质素过氧化物酶突变体及其基因、工程菌、制备方法与应用, ZL202411171014.X.

[4] 漆酶突变体、基因工程菌及其应用, ZL202310820543.7.

[5] 一种木质素及其衍生炭在厌氧消化中的应用, ZL201910001814.X.

[6] 一种低碳环保融雪剂制备方法, ZL201711168058.7

获奖情况

无。

联系方式

办公地点：天津经济技术开发区第十三大街29号天津科技大学生物工程学院

邮政编码：300457

Email： zhaolei2024@tust.edu.cn