赵桂红，博士，毕业于江南大学。天津科技大学生物工程学院博士后。

科研领域及方向

[1]利用合成生物学和代谢工程手段构建氨基酸、核苷及衍生产品的高效生产菌株。

[2]从事大肠杆菌、谷氨酸棒杆菌和需钠弧菌基因组编辑技术和系统生物学研究。

[3]研究微生物发酵过程规律，优化发酵工程技术提高产物滴度、得率和合成效率。

主要学术成果

先后发表各类科研论文18篇，授权发明专利1项。发表的主要学术论文有：

[1] Zhao, G.; Zhang, D.; Li, R.; Tang, Y.; Wang, J.; Hu, X.; Wang, X. Regulatory mechanism of ferrous ion in enhancing the biosynthesis of L-homoserine, L-threonine, and L-isoleucine in Corynebacterium glutamicum. World Journal of Microbiology and Biotechnology 2025, 41 (10), 407.

[2] Zhao, G.; Tang, Y.; Zhang, D.; Liu, G.; Li, Z.; Li, R.; Hu, X.; Wang, J.; Wang, X. Engineering homoserine kinase for competitive inhibition release to enhance L-threonine production in Corynebacterium glutamicum. International Journal of Biological Macromolecules 2025, 321.

[3] Zhao, G.; Tang, Y.; Li, Z.; Liu, G.; Zhang, D.; Hu, X.; Wang, X. Engineering Corynebacterium glutamicum for efficient L-homoserine production. Bioresource Technology 2025, 431, 132617.

[4] Zhao, G.; Zhang, D.; Tang, Y.; Hu, X.; Wang, X. Recent advances on engineering Escherichia coli and Corynebacterium glutamicum for efficient production of L-threonine and its derivatives. Metabolic Engineering 2025, 90, 1-15.

[5] Zhao, G.; Zhang, D.; Zhou, B.; Li, Z.; Liu, G.; Li, H.; Hu, X.; Wang, X. Fine-regulating the carbon flux of L-isoleucine producing Corynebacterium glutamicum WM001 for efficient L-threonine production. ACS Synthetic Biology 2024, 13 (10), 3446-3460.

[6] Tian, S.1; Zhao, G.1; Lv, G.; Wu, C.; Su, R.; Wang, F.; Wang, Z.; Liu, Y.; Chen, N.; Li, Y. Efficient fermentative production of D-alanine and other D-amino acids by metabolically engineered Corynebacterium glutamicum. Journal of Agricultural and Food Chemistry 2024, 72 (14), 8039-8051.

[7] Zhao, G.; Su, R.; Yuan, M.; Ma, H.; Bo, T.; Jiang, H.; Wu, C.; Li, Y. Physiological responses of ribosomal protein S12 K43 mutants of Corynebacterium glutamicum. Current Microbiology 2022, 79 (3), 94.

[8] Li, Z.; Zhao, G.; Zhang, D.; Tang, Y.; Liu, G.; Wang, X. Metabolic engineering Corynebacterium glutamicum ATCC13032 for 2′-fucosyllactose production. Systems Microbiology and Biomanufacturing 2025, 5 (3), 1084-1099.

[9] Liu, G.; Zhao, G.; Liu, H.; Zhang, D.; Tang, Y.; Li, Z.; Wang, X. Identification of lipid A Kdo transferase encoded by BT_2747 in Bacteroides thetaiotaomicron VPI 5482. Systems Microbiology and Biomanufacturing 2025, 5 (4), 1536-1554.

[10] Zhou, B.; Zhao, G.; Yu, J.; Wang, Y.; Zhang, D.; Hu, X.; Wang, X. Multi-step metabolic engineering Corynebacterium glutamicum ATCC 13032 to produce L-methionine. Systems Microbiology and Biomanufacturing 2025, 5 (2), 593-610.

[11] Huang, Y.; Li, H.; Zhao, G.; Hu, X.; Wang, X. Metabolic engineering of Corynebacterium glutamicum for L-alanine production. Systems Microbiology and Biomanufacturing 2025, 5 (1), 261-275.

[12] Li, Z.; Zhang, D.; Tang, Y.; Zhao, G.; Liu, G.; Wang, X. Combinatorial metabolic engineering and whole-cell biocatalysis enable high-level lacto-N-neotetraose production in Corynebacterium glutamicum. Systems Microbiology and Biomanufacturing 2025, 6 (1), 5.

[13] Liu, G.; Huang, D.; He, F.; Zhao, G.; Wang, Y.; Li, Z.; Chen, L.; Wang, X. Substrate specificity of lipid A 4′-phosphatase in Bacteroides thetaiotaomicron. Food Bioscience 2025, 66, 106302.

[14] Zhang, Y.; Wei, M.; Zhao, G.; Zhang, W.; Li, Y.; Lin, B.; Li, Y.; Xu, Q.; Chen, N.; Zhang, C. High-level production of L-homoserine using a non-induced, non-auxotrophic Escherichia coli chassis through metabolic engineering. Bioresource Technology 2021, 327.

[15] Li, H.; Xu, D.; Tan, X.; Huang, D.; Huang, Y.; Zhao, G.; Hu, X.; Wang, X. The role of trehalose biosynthesis on mycolate composition and L-glutamate production in Corynebacterium glutamicum. Microbiological Research 2023, 267.

[16] Li, H.; Xu, D.; Zhang, D.; Tan, X.; Huang, D.; Ma, W.; Zhao, G.; Li, Y.; Liu, Z.; Wang, Y.; et al. Improve L-isoleucine production in Corynebacterium glutamicum WM001 by destructing the biosynthesis of trehalose dicorynomycolate. Microbiological Research 2023, 272.

[17] Wang, T.; Li, Y.; Li, J.; Zhang, D.; Cai, N.; Zhao, G.; Ma, H.; Shang, C.; Ma, Q.; Xu, Q.; Chen, N. An update of the suicide plasmid-mediated genome editing system in Corynebacterium glutamicum. Microbial Biotechnology 2019, 12 (5), 907-919.

[18] Ma, H.; Fan, X.; Cai, N.; Zhang, D.; Zhao, G.; Wang, T.; Su, R.; Yuan, M.; Ma, Q.; Zhang, C.; et al. Efficient fermentative production of L-theanine by Corynebacterium glutamicum. Applied Microbiology and Biotechnology 2020, 104 (1), 119-130.

授权发明专利主要有：

[1] 李燕军，赵桂红，张成林等（2021）《微生物发酵法制备D-丙氨酸的方法》ZL 202110572350.5

获奖情况

联系方式

办公地点：天津经济技术开发区第十三大街29号天津科技大学生物工程学院

邮政编码：300457

办公电话：022-6060xxxx

传 真：022-60602298

Email：ghzhao@tust.edu.cn