天津科技大学生物工程学院欢迎您!
副教授

孟欣医学博士,研究员,制药工程教研室主任,研究生党支部书记天津市131人才第三层次天津市科技特派员(入驻康希诺生物股份公司),中国化学会会员,天津微生物学会会员2014年获山东大学微生物生化药学博士学位;20185-20195美国SCRIPPS研究所进行访问学者研究。

主讲课程

本科生:《化学制药工艺学》

研究生:生物糖类药物英语生物医药管理法规

主要教学研究及成果情况

目前参编教材52019年度津市工程专业学位优秀教学成果一等奖

研领域及方向

[1] 基于糖类肿瘤药物合成活性评价糖类疫苗研制

[2] 功能化学酶法合成构效关系研究

[3] 多糖仿生材料功能开发应用。

科研项目情况

[1] 国家自然科学基金,新型区域选择性化学酶法合成双唾液酸化TF及其氟代衍生物和其在肿瘤疫苗中的应用研究,主持2016-2018

[2] 天津市技术创新引导专项优秀科技特派员项目, 新型PGL-tb1结核疫苗的研制, 主持2015-2016

[3] 工业发酵微生物教育部重点实验室暨天津市工业微生物重点实验室主任基金;益生元唾液酸乳糖的固定化酶酶法合成,主持2016-2018

[4] 国家自然科学基金,人皮瓣内切酶抑制剂的设计、筛选及抑癌活性研究,2016-2018,第二参与人

[5] 天津科技大学大学生实验室创新基金重点项目肿瘤相关糖抗原氟代衍生物的化学酶法合成及其在肿瘤疫苗中的应用主持2016-2018

[6] 卫生部重大新药创制科技重大专项子课题腺病毒培养及纯化工艺研究,2015ZX09J15105-002-0032015-2018,第二参与人

[7] 横向项目氟代细菌荚膜多糖结合疫苗的开发2020-2021主持。

[8] 横向项目液相色谱检测2020-2023主持。

[9] 横向项目1900040000),神经节苷脂GM3的制备研究,2018-2020主持。

[10] 横向项目糖类二维杂原子测试2020-2021主持。

[11] 横向项目1400040028),十三价肺炎结合疫苗的开发,2014-2016,第二参与人

主要学术成果

先后发表各类科研论文20篇,授权申请发明专利10项。发表的主要学术论文有:

[1] Tao Liu, Zhuoran Zhang, Peijie Dong, Feng Tian, Fan Li* and Xin Meng*. Electrospun kaolin-loaded chitosan/PEO nanofibers for rapid hemostasis and accelerated wound healing. Nanoscale, 2022, under review.

[2] Tingshen Li#, Xiaodan Wang#, Peijie Dong, Peng Yu, Yongmin Zhang, Xin Meng*. Chemoenzymatic synthesis and biological evaluation of ganglioside GM3 and lyso-GM3 as potential agents for cancer therapy. Carbohydrate Research, 2021, 509 108431.

[3] Tingshen Li#, Peng Yu#, Yihao Chen, Baoying Sun, Peijie Dong, Tao Zhu, Xin Meng*. N-acetylgalactosamine-decorated nanoliposomes for targeted delivery of paclitaxel to hepatocellular carcinoma. European Journal of Medicinal Chemistry, 2021, 222, 113605.

[4] XinMeng*, YangLu, YingGao, SuyingCheng, FengTian, Yuliang Xiao*, FanLi*. Chitosan/alginate/hyaluronic acid polyelectrolyte composite sponges crosslinked with genipin for wound dressing application. International Journal of Biological Macromolecules, 2021, 182, 512-523.

[5] Xin Meng, Yiwu Pan, Tao Liu, Chen Luo, Shuli Man, Yongmin Zhang, Yan Zhang*. Synthesis of novel diosgenyl saponin analogs and evaluation effects of rhamnose moeity on their cytotoxic activity. Carbohydrate Research, 2021, 506, 108359.

[6] Tiantian Hao#, Haomeng Wang#, Jiacheng Liu, Qian Zhang, Yuning Liu, Lianbo Zhao, Tao Zhu, Peng Yu, Na Guo*, Xin Meng*. Synthesis and immunogenicity of Brucella monovalent neoglycoconjugate. Carbohydrate Research, 2020, 108196.

[7] Tingshen Li, Huiming Zhang, Ying Guo, Tao Zhu, Peng Yu, Xin Meng*. Efficient chemoenzymatic synthesis of fluorinated sialyl Thomsen-Friedenreich antigens and investigation of their characteristics. European Journal of Medicinal Chemistry, 2020 208, 112776.

[8] Xin Meng*, Xujing Lian, Xiao Li, Qiang Ya, Tingshen Li, Yongmin Zhang, Yang Yang*, Yan Zhang*. Synthesis of 2′-paclitaxel 2-deoxy-2-fluoro-glucopyranosyl carbonate for specific targeted delivery to cancer cells. Carbohydrate Research, 2020, 493, 108034.

[9] Xin Meng#, Honghong Dong#, Pan Yiwu, Long Ma, Changxiao Liu, Man Shuli*, Gao Wenyuan*. Diosgenyl saponin inducing endoplasmic reticulum stress and mitochondria-mediated apoptotic pathways in liver cancer cells. Journal of Agricultural and Food Chemistry, 2019, 67 (41), 11428-11435.

[10] Yunsong Chang#, Xin Meng#,*, Yaxin Li, Jianmei Liang, Tingshen Li, Demei Meng, Tao Zhu and Peng Yu*. Synthesis and immunogenicity of Mycobacterium tuberculosis arabinomannan-CRM197 conjugate. MedChemComm, 2019, 10 (4), 543-553.

[11] Mingyuan Li, Chunyang Du, Na Guo, Yuou Teng, Xin Meng, Hua Sun, shuangshuang Li, Peng Yu*, Herve Galons. Composition design and medical application of liposomes. European Journal of Medicinal Chemistry. 2019, 164, 640-653.

[12] Hai-Peng Liu#, Xin Meng#, Qun Yu, Yun-Chang Tao, Hao-Jie He, Yao Yu, Hao Chang, Yun He, Peng Yu*, Yang Yang*. Synthesis of S-sialyl polymers as efficient polyvalent influenza inhibitors and captures. Journal of Carbohydrate Chemistry. 2018,37 (1), 18-29.

[13] Xin Meng*, Meibing Yang, Yang Li, Xiaobin Li, Tianwei Jia, Haojie He, Qun Yu, Na Guo, Yun He, Peng Yu, Yang Yang. Multivalent neuraminidase hydrolysis resistant triazole-sialoside protein conjugates as influenza-adsorbents. Chinese Chemical Letters, 2018, 29, 76–80.

[14] De-Min Wang#, Xin Meng#, Xiao-Bin Li, Hao-Jie He, Teng-Fei Zhao, Tian-Wei Jia, Yun He,Yang Yang* and Peng Yu*. Modification of bovine serum albumin with aminophenylboronic acid as glycan sensor based on surface plasmon resonance and isothermal titration calorimetry. Heterocyclic Communications, 2017, 23(3): 237–243. [15] Xin Meng, Chuanming Ji, Chao Su, Di Shen, Yaxin Li, Peijie Dong, Ding Yuan, Mengya Yang, Song Bai, Demei Meng, Zhenchuan Fan, Yang Yang*, Peng Yu*, Tao Zhu*. Synthesis and immunogenicity of PG-tb1 monovalent glycoconjugate. European Journal of Medicinal Chemistry, 2017, 134, 140-146.

[16] Yang Yang, Hai-Peng Liu, Qun Yu, Mei-Bing Yang, De-Min Wang, Tian-Wei Jia, Hao-Jie He, Yun He, Hai-Xia Xiao, Suri S. Iyer, Zhen-Chuan Fan, Xin Meng*, Peng Yu*. Multivalent S-sialoside protein conjugates block influenza hemagglutinin and neuraminidase. Carbohydrate Research, 2016, 435, 68–75.

[17] Pan Guojun, Xiao Na, Shen Di, Chen Minglang, Li Yi, Lu Kui,Yang Yang, Meng Xin*, Yu Peng*, Synthesis and hypoglycemic activity of novel quercetin conjugates [J], Chin. J. Org. Chem2017, 37 (1) :133-140.

[18] Xin Meng, Wenlong YaoJiansong ChengXu ZhangLan JinHai YuXi ChenFengshan Wang*Hongzhi Cao*Regioselective chemoenzymatic synthesis of ganglioside disialyl tetrasaccharide epitopes. Journal of the American Chemical Society2014, 13614: 5205-5208.

授权发明专利主要有:

[1] Meng Xin, Yu Peng, Li Yaxin, Lian Xujing, Li Tingshen. FLUORINATED-SUGAR MODIFIED PACLITAXEL AND ITS SYNTHESIS AND APPLICATION [P], 2020, AU2020101555

[2] 孟欣。唾液酸化TF原及其氟代衍生物的合成方法及其应用 [P]ZL201711385873.9

[3] 孟欣 一种结杆菌PGL-tb1寡糖缀合物及其制备方法与应用 [P]ZL201610788095.7

[10] 曹鸿志,王凤山,孟欣。四糖MAG拮抗剂的合成方法,ZL201310508204.1

[11] 曹鸿志,王凤山,孟欣。双唾液酸化四糖的合成方法, ZL 20130508766.6

获奖情况

2018年全国巾帼文明岗成员2019年天津市三八红旗集体成员2021天津科技大学首届教师教学创新大赛优秀奖

联系方式

办公地点:天津经济技术开发区第十三大街29号天津科技大学生物工程学院

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办公电话:022-60912562

传 真:022-60602298

Emailmengxin@tust.edu.cn