天津科技大学生物工程学院欢迎您!
副教授

马倩博士,副教授,硕士生导师。天津市“131”人才计划第三层次人选。天津微生物学会会员

主讲课程:

本科生:生物工程概论

本科生:氨基酸工艺学

科研领域及方向

[1] 氨基酸及衍生物生产菌株构建

[2] 功能糖及衍生物生产菌株构建

[3] 发酵过程系统生物学解析

科研项目情况

[1] 主持国家重点研发计划(绿色生物制造)子课题项目,所属项目为:工业菌种基因组人工重排技术(2021YFC2100800),2021/7-2024/6,在研

[2] 主持国家自然科学基金青年项目:大肠杆菌中羟基四氢嘧啶可控合成体系的构建与调控研究(21808168),2019/1-2021/1,结题

[3] 主持天津市自然科学基金青年项目:谷氨酸棒杆菌分支链氨基酸合成途径中关键蛋白相互作用研究(17JCQNJC09500),2017/4-2020/3,结题

[4] 参与国家重点研发计划课题:高版本模式微生物底盘细胞系统集成与功能测试(2018YFA0900304),2019/07-2024/06,在研

[5] 参与国家自然科学基金面上项目动态调节谷氨酸棒杆菌TCA循环调控4-羟基异亮氨酸高效合成的机制研究321700492022/01/01-2025/12/31,在研

[6] 参与山东省重点研发计划(重大科技创新工程)项目:一步混菌发酵制备维生素C2022CXGC0105062022/2-2025/2,在研

主要学术成果

先后发表各类科研论文20余篇,授权发明专利6项。

发表的主要学术论文有:

[1] Ma Q, Xia L, Wu H, Zhuo M, et al. Metabolic engineering of Escherichia coli for efficient osmotic stress-free production of compatible solute hydroxyectoine. Biotechnology and Bioengineeing. 2022, 119(1): 89-101

[2] Ma Q, Sun Q, Tan M, Xia L, et al. Highly efficient production of N‑acetyl-glucosamine in Escherichia coli by appropriate catabolic division of labor in the utilization of mixed glycerol/glucose carbon sources. Journal of Agricultural and Food Chemistry, 2021, 69: 5966−5975

[3] Hao Y#, Ma Q#, Liu X, Fan X, et al. High-yield production of L-valine in engineered Escherichia coli by a novel two-stage fermentation. Metabolic Engineering, 2020, 62: 198-206

[4] Zhang Q#, Hou Z#, Ma Q#, Mo X, et al. CRISPRi-based dynamic control of carbon flow for efficient N‑acetyl glucosamine production and its metabolomic effects in Escherichia coli. Journal of Agricultural and Food Chemistry, 2020, 68: 3203−3213

[5] Ma Q, Bi Y, Wang E, Zhai B, et al. Integrated proteomic and metabolomic analysis of a reconstructed three‑species microbial consortium for one‑step fermentation of 2‑keto‑l‑gulonic acid, the precursor of vitamin C. Journal of Industrial Microbiology & Biotechnology, 2019, 46(1): 21-31

[6] Ma Q, Zhang Q, Xu Q, Zhang C, et al. Systems metabolic engineering strategies for the production of amino acids. Synthetic and Systems Biotechnology, 2017, 2: 87-96

[7] Ma Q, Zou Y, Lv Y, Song H, et al. Comparative proteomic analysis of experimental evolution of the Bacillus cereus-Ketogulonicigenium vulgare co-culture. Plos One, 2014, 9(3): e91789

[8] Ma Q, Wang J, Lu S, Lv Y, et al. Quantitative proteomic profiling reveals photosynthesis responsible for inoculum size dependent variation in Chlorella sorokiniana. Biotechnology and Bioengineering, 2013, 110(3): 773-784

[9] Ma Q, Zhang W, Zhang L, Qiao B, et al. Proteomic analysis of Ketogulonicigenium vulgare under glutathione reveals high demand for thiamin transport and antioxidant protection. Plos One, 2012, 7(2): e32156

[10] Ma Q, Zhou J, Zhang W, Meng X, et al. Integrated proteomic and metabolomic analysis of an artificial microbial community for two-step production of vitamin C. Plos One, 2011, 6(10): e26108

[11] Wang E, Ding M, Ma Q, et al. Reorganization of a synthetic microbial consortium for one-step vitamin C fermentation. Microbial Cell Factories, 2016, 15(1): 15-21

授权发明专利主要有:

[1] 马倩孙全伟谭淼夏利张颖杨蒙雅谢希贤陈宁徐庆阳张成林李燕军范晓光. 一种产N-乙酰氨基葡萄糖的基因工程菌及其应用2022.2.22中国ZL202011398296.9

[2] 马倩,谢希贤,陈宁,张权威,等,一种产生N-乙酰氨基葡萄糖的基因工程菌及其应用,2021.1.22ZL201810503190.7

[3] 元英进,马倩,陆姝欢,吕亚金,一种微藻蛋白质组的分析方法,2014.4.16ZL201210159134.9

[4] 元英进,马倩,张璐,检测谷胱甘肽作用于氧化葡糖杆菌过程中细胞内蛋白质变化的方法,2014.1.22ZL201110346058.8

[5] 元英进,马倩,米造吉,谢萍,检测维生素C工业混菌发酵过程中细胞内蛋白质变化方法,2013.5.8ZL201110065051.9

[6] 元英进,仪宏,王丽丽,周剑,马倩,薛佳,提高氧化葡糖杆菌产2--L-古龙酸的方法,2011.6.1ZL200910069697.7

联系方式

办公地点:天津经济技术开发区第十三大街29号天津科技大学生物工程学院

邮政编码:300457

办公电话:022-60601251

传 真:022-60602298

Emailqianma1987@tust.edu.cn