
张翠英,博士,天津科技大学生物工程学院教授,博士生导师。天津市“131”人才计划第一层次人选,天津市高校“学科领军人才”,天津市高校“优秀青年教师”,天津市高校“优秀青年研究生指导教师”,“伦世仪教育基金杰出青年学者”。中国轻工业微生物工程重点实验室主任,中国酒业协会产业创新技术研究院副院长,中酒协白酒分会技术委员会副秘书长,全国白酒标准化技术委员会委员。中国生物发酵产业协会酵母分会理事,天津市微生物学会常务理事,天津市微量元素学会常务理事。
主讲课程:
本科生:《酿造酒工艺学》、《酿酒工艺学》、《“非物质文化遗产”中的酿酒技艺》
研究生:《现代酿酒科学与技术》、《生物分离原理与技术》、《生物与制药分离技术与工程》
主要教学研究及成果情况
指导大学生创新创业训练计划项目2项,主编教材1部,参编教材3部,第一完成人获得天津科技大学校级研究生教学成果一等奖1项,第二完成人获得天津市教学成果特等奖1项,指导硕士研究生获得天津市工程专业学位硕士研究生优秀学位论文。
科研领域及方向
主要围绕工业微生物与传统发酵食品开展以下四个方面的研究:
[1] 酒类发酵机理研究与智能制造:传统发酵食品酿造机理解析、酿酒工艺数智化、酒类精准发酵技术开发、新型酒类产品开发;
[2] 酒类风味分析与活性功能研究:酒类产品微量成分的定性与定量分析、食品中微量成分与活性物质的功能评价与机制解析;
[3] 合成生物学与生物制造:高耐性微生物细胞底盘的开发、香精香料和功能因子的生物合成、传统发酵食品的合成微生物组学研究;
[4] 微生物资源的开发与利用:工业微生物菌种筛选与特色资源库建立、重要工业微生物代谢调控与分子育种、微生物菌剂制备与应用。
主持科研项目情况
[1] 国家自然科学基金面上项目:粟酒裂殖酵母响应酸胁迫的分子基础及其对白酒风味发酵的影响机制,2025.01-2028.12,合同编号:32472317
[2] 国家重点研发计划课题:含氮化合物高效合成细胞工厂构建与生产示范,2023.12-2028.11,合同编号:2023YFA0914504
[3] 宁夏重点研发计划项目:基于风味与健康双导向的贺兰山东麓葡萄酒合成微生物关键酿造技术的开发与应用,2022.01-2025.12,合同编号:2023BCF01028
[4] 天津市重点研发计划科技支撑重点项目:基于风味导向的‘玫瑰香’葡萄酒合成微生物组关键酿造技术的开发与应用,2023.10-2026.09,合同编号:23YFZCSN00300
[5] 天津市科技计划项目:大曲品质数字化表达及质量提升技术开发,2022.01-2023.09,合同编号:22ZYJDSS00050
[6] 贵州国台酒业集团股份有限公司技术服务项目:酱酒酿造微生态三系标准评价体系及调控技术开发,2024.03-2027.03,合同编号:2400040116
[7] 河北琢酒集团技术服务项目:琢酒饮后舒适物质基础解析及微生态调控技术开发,2023.05-2028.05,合同编号:2300040110
[8] 四川省古蔺郎酒厂有限公司技术服务项目:庄园酱酒饮后舒适度及其风味属性解析,2024.02-2027.02,合同编号:2400040020
[9] 贵州习酒股份有限公司技术服务项目:酱香型白酒微生物菌剂研发及产业化示范研究,2023.04.30-2024.04.30,合同编号:2300040059
[10] 贵州珍酒酿酒有限公司委托项目:珍酒低醉酒度的分子机制与品质控制关键酿造技术研究,2021.7.1-2024.6.30,合同编号:2100040041
主要学术成果
先后发表各类科研论文200余篇,授权发明专利48项。发表的主要学术论文有:
[1] Systems metabolic engineering of Escherichia coli for efficient de novo biosynthesis of 2,5-Dimethylpyrazine from glucose. Journal of Agricultural and Food Chemistry, 2026 Mar 13.
[2] Deciphering the mechanism underlying the n-propanol accumulation in Baijiu fermentation: A novel perspective from the interplay between acetic acid and microbial metabolism. Food Bioscience, 2026, 108660.
[3] Digital transformation of Jiangxiangxing Baijiu production: integrating flavor compound analysis, machine learning recognition, and genetic algorithm blending of multi-rounds. Food Research International, 2026, 230, 118635.
[4] Strain-specific impacts of Pichia kudriavzevii on metabolite profiles and microbial community dynamics in Chinese Baijiu fermentation: Integrated metabolomics and metagenomics analysis. International Journal of Food Microbiology, 2026, 450, 111660.
[5] Non-volatile compounds as aroma modulators in Jiangxiang-flavor Baijiu: Regional flavor differentiation and synergistic interactions with volatile aromas. Food Chemistry, 2025, 490, 145015.
[6] Ethyl lactate ameliorates hepatic steatosis and acute-on-chronic liver injury in alcohol-associated liver disease by inducing fibroblast growth factor 21. Advanced Science. 2025, 12, 2409516.
[7] Unveiling the yeast interaction: Insights into the role of Saccharomyces cerevisiae metabolites in regulating Torulaspora delbrueckii aroma biosynthesis during wine fermentation. International Journal of Food Microbiology, 2025, 443, 111415.
[8] The insight into instability mechanism of Jiangxiangxing Baijiu fermentation and the key functional regulation of Schizosaccharomyces pombe. Food Chemistry: X, 2025, 31, 103085.
[9] Unraveling flavor formation in Jiuqu: Source pathways, influencing factors, and regulatory strategies. Food Chemistry: X, 2025, 31, 103009.
[10] Microbiomics and machine learning-assisted approaches reveal amino acid patterns in high-temperature Daqu. Food Chemistry, 2025, 492, 145378.
[11] The discrepancy in amino acids within high-temperature Daqu: A novel metabolic marker for the quality evaluation of Daqu. Food Chemistry, 2025, 470, 142645.
[12] Recent advances in analytical approaches for aroma interaction of fermented foods: A review. Food Chemistry, 2025, 495, Part 3, 146544.
[13] Effects of Heterologous Expression of Genes Related L–Malic acid Metabolism in Saccharomyces uvarum on Flavor Substances Production in Wine. Foods, 2024, 13, 2038.
[14] Research on Engineering the Saccharomyces uvarum for Constructing a High Efficiency to Degrade Malic Acid and Low Yield of Diacetyl Biosynthesis Pathway. Foods, 2024, 13, 3161.
[15] Investigation of novel metabolites generated by Torulaspora delbrueckii to promote the aroma biosynthesis in Saccharomyces cerevisiae during wine fermentation. LWT, 2024, 211, 116816.
[16] Improving muscat hamburg wine quality with innovative fermentation strategies using Schizosaccharomyces pombe derived from fermented grains of sauce-flavor Baijiu. Foods, 2024, 13, 1648.
[17] Heterogenetic mechanism in high-temperature Daqu fermentation by traditional craft and mechanical craft: From microbial assembly patterns to metabolism phenotypes. Food Research International, 2024, 187: 114327.
[18] Unraveling the chemosensory characteristics dependence of sauce-flavor baijiu on regionality using descriptive sensory analysis and quantitative targeted flavoromics. Food Chemistry, 2024, 441:138274.
[19] Biosynthesis of α-bisabolene from low-cost renewable feedstocks by peroxisome engineering and systems metabolic engineering of the yeast Yarrowia lipolytica. Green Chemistry, 2023, 25 (20), 8145-8159.
[20] Using in situ untargeted flavoromics analysis to unravel the empty cup aroma of Jiangxiang-type Baijiu: A novel strategy for geographical origin traceability. Food Chem, 2024, 438:137932.
[21] Combining metabolic engineering and lipid droplet storage engineering for improved α-bisabolene production in Yarrowia Lipolytica. Journal of Agricultural and Food Chemistry, 2023, 71(30):11534-11543.
[22] Genome-wide analysis reveals Hsf1 maintains high transcript abundance of target genes controlled by strong constitutive promoter in Saccharomyces cerevisiae. Biotechnology for Biofuels and Bioproducts, 2023, 16(1):72.
[23] Analysis of the effect of mixed fermentation on the quality of distilled jujube liquor by gas chromatography-ion mobility spectrometry and flavor sensory description. Foods, 2023, 12(4):795.
[24] The eisosomes contribute to acid tolerance of yeast by maintaining cell membrane integrity. Food Microbiology, 2023, 110:104157.
[25] Using transcriptomics to reveal the molecular mechanism of higher alcohol metabolism in Saccharomyces cerevisiae. Food Bioscience, 2023, 51: 102227.
[26] Regulating the ratio of higher alcohols to esters by simultaneously overexpressing ATF1 and deleting BAT2 in brewer's yeast Saccharomyces pastorianus. Food Bioscience, 2021, 3:101231.
[27] Improve the production of D-limonene by regulating the mevalonate pathway of Saccharomyces cerevisiae during alcoholic beverage fermentation. Journal of Industrial Microbiology & Biotechnology, 2020, 47(12):1083-1097.
[28] Engineering Saccharomyces cerevisiae for production of the valuable monoterpene d-limonene during Chinese Baijiu fermentation. Journal of Industrial Microbiology & Biotechnology, 2020, 47(6-7):511-523.
[29] Increasing yield of 2,3,5,6-tetramethylpyrazine in Baijiu through Saccharomyces cerevisiae metabolic engineering. Frontiers in Microbiology, 2020, 11:596306.
[30] Effect of ILV2 deletion and ILV3 or/and ILV5 overexpression in Saccharomyces uvarum on diacetyl and higher alcohols metabolism during wine fermentation. European Food Research and Technology, 2020, 246:563-572.
授权发明专利主要有:
[1] 张翠英,卢君,等。一株高耐酸粟酒裂殖酵母及在酱香型白酒酿造中的应用,中国发明专利,授权号:ZL202110280090.4
[2] 张翠英,卢君,等。一种具有乙酸高耐受性的粟酒裂殖酵母,中国发明专利,授权号:ZL202110289723.8
[3] 张翠英,林良才,等。一种高耐酸能力的粟酒裂殖酵母菌及其构建方法,中国发明专利,授权号:ZL202210534916.X
[4] 张翠英,林良才,等。一株拜耳接合酵母及其在白酒生产中的应用,中国发明专利,授权号:ZL202310403027.4
[5] 张翠英,李彤,等。一种低产高级醇和强降解苹果酸的葡萄汁酵母菌株及其应用,中国发明专利,授权号:ZL201911231057.1
[6] 张翠英,肖冬光,等。一种高效的酿酒酵母无痕基因敲除方法及其应用,中国发明专利,授权号:ZL201810748064.8
[7] 张翠英, 肖冬光, 等。一株高耐性酵母菌株及其构建方法,中国发明专利,授权号:ZL201410277435.0
[8] 张翠英, 肖冬光, 等。耐高糖面包酵母菌株的构建及其选育方法,中国发明专利,授权号:ZL201410472561.1
[9] 张翠英, 肖冬光, 等。一株适合不加糖面团发酵的面包酵母及其选育方法,中国发明专利,授权号:ZL201410333534.6
[10] 张翠英, 肖冬光, 等。一种适合于冷冻面团发酵的耐冷冻活性干酵母,授权号:ZL201310153755.0
获奖情况
[1] 发酵食品精准酿造体系与装备创新及应用,天津市科技进步二等奖,2026
[2] 化妆品功效因子及基材生物制造关键技术开发与应用,中国轻工业联合会科学技术进步二等奖,2025
[3] 数智驱动的酱香白酒生产全过程质量技术集成研究与应用,中国质量协会质量技术三等奖,2025
[4] 酱香型白酒发酵过程微生态调控及品质提升关键技术及应用,天津市食品学会科技进步二等奖,2025
[5] 原生质体诱变—环境胁迫定向选育耐受菌株精准酿造关键技术及应用,江西省科技进步一等奖,2024
[6] 第二十届中国青年女科学家奖天津候选人,2024
[7] 酱香型白酒发酵过程微生态调控及品质提升关键技术与应用,中国酒业协会科学技术进步二等奖,2024
[8] 基于风味定量组学的酱香型白酒品质解析及关键技术创制与应用,中国食品工业协会科学技术三等奖,2024
[9] 山庄皇家窖藏酒品质控制关键技术研究与低醉酒度产品的开发,河北省食品工业协会科学技术特等奖, 2023
[10] 一种高产酯酿酒酵母基因工程菌及其构建方法,中国专利优秀奖,2022
[11] 优质白酒酿造关键技术及其应用,首届天津市食品学会食品科技创新奖科技进步一等奖,2021
[12] 一种高产酯酿酒酵母基因工程菌及其构建方法,天津市专利金奖,2020
[13] 高产酯酿酒酵母菌株的选育与应用。中国轻工联合会科学技术进步三等奖,2017
[14] 高耐性酵母关键技术研究与产业化,国家科技进步二等奖,2014
[15] 浓醪发酵关键技术研究及在酒精生产节能减排中的应用,中国食品科学技术学会技术进步奖一等奖,2010
[16] 浓醪发酵生产燃料乙醇关键技术研究与产业化,中国轻工业联合会科学技术二等奖,2010
联系方式
办公地点:天津经济技术开发区第十三大街29号天津科技大学生物工程学院
邮政编码:300457
办公电话:022-60602045
传 真:022-60602298
Email: cyzhangcy@tust.edu.cn