天津科技大学生物工程学院欢迎您!
教授

毛淑红,博士,天津科技大学生物工程学院教授,博士生导师。

主讲课程:

本科生:微生物学,微生物学实验

主要教学研究及成果情况

先后主持或参与教改项目1项,发表教改论文2篇,主编或参编教材或专著3部。

[1] 天津科技大学教育教学改革项目:基于微生物学的课程思政教学改革与设计, 主持;

科研领域及方向

[1] 生物工程:生物催化与生物转化;

[2] 生物与医药:甾体化合物生物催化机理研究;

科研项目情况

[1] 国家自然科学基金面上项目:基于低溶点共熔溶剂的甾体化合物高效微生物全细胞催化脱氢体系研究, 2019.01-2022.12,主持;

[2] 国家自然科学基金项目:离子液体双液相甾体生物催化体系构建研究,2013-2015,主持;

[3] 天津市自然科学基金面上项目:简单节杆菌高活力C1,2位脱氢酶的分子改造及其构效关系研究,2018.10-2021.09,主持;

[4] 天津市自然科学基金青年基金,离子液体两相系统雷斯青霉催化左旋乙基甾烯双酮研究,2012.04-2015.03,主持;

[5] 国家重点研发项目:甾体激素从头合成途径的设计与验证,2020.01-2024.12,子任务负责人;

[6] 天津市合成生物技术创新能力提升行动项目:羟基化氨基酸高效生物合成关键技术开发2021.1-2023.12.主持

主要学术成果

先后发表各类科研论文20余篇,授权发明专利6项。发表的主要学术论文有:

[1] Shuhong Mao, Xin Liu, Xin Gao, Zhangliang Zhu, Dengyue Sun, Fuping Lu, Hui-Min Qin, Design of an efficient whole-cell biocatalyst for the production of hydroxyarginine based on a multi-enzyme cascade, Bioresource Technology, 2020, 318: 124261.

[2]Shuhong Mao, Sun Jing, Lanlan Wang, Xin Gao, Xiaoguang Liu, Fuping Lu, Hui-Min Qin, Mining and characterization of 3-ketosteroid-Δ1 -dehydrogenases from Arthrobacter simplex genome and applications for steroid dehydrogenation, Biochemical Engineering Journal, 2022, 181: 108383.

[3] Shuhong Mao, Zhaohui Zhang, Xiaoyu Ma , Huan Tian, Fuping Lu*, Yihan Liu*Efficient secretion expression of phospholipase D in Bacillus subtilis and its application in synthesis of phosphatidylserine by enzyme immobilization. International Journal of Biological Macromolecules, 2021,169:282-289.

[4]Mao, Shuhong, Wang, Jian-Wen, Liu, Fufeng, Zhu, Zhangliang, Gao, Dengke, Guo, Qianqian, Xu, Panpan, Ma, Zheng, Hou, Yali, Cheng, Xiaotao, Sun, Dengyue, Lu, Fuping, Qin, Hui-Min. Engineering of 3-ketosteroid -Delta(1)-dehydrogenase based site-directed saturation mutagenesis for efficient biotransformation of steroidal substrateMicrobial Cell Factories2018,09: 141

[5] Shuhong Mao, Zhan Song, Mian Wu, Xiaorui Wang, Fuping Lu and Hui-MinQin, Expression, purification, refolding, and characterization of a neverland protein from Caenorhabditis elegans. Frontiers in Bioengineering and Biotechnology, 2020, 08: 593041.

[6] Shuhong Mao, Xiaorui Wang, Zhaohui Zhang, Shan Wang, Kang Li, Fuping Lu, Huimin Qin, 15α-hydroxylation of D-ethylgonendione by Penicillium raistrickii in deep eutectic solvents DESs containing system. Biochemical Engineering Journal, (2020) 164: 107781.

[7] Mao, Shuhong, Liu, Yanna, Yang, Juanjuan, Ma, Xiaoyu, Zeng, Fang, Zhang, Zhaohui, Wang, Shan, Han, Haichao, Qin, Hui-Min, Lu, Fuping, Cloning, expression and characterization of a novel fructosyltransferase from Aspergillus niger and its application in the synthesis of fructooligosaccharides. RSC Advances, 2019, 9(41): 23856-23863.

[8] Shuhong Mao, Xiaotao Cheng, Zhangliang Zhu, Ying Chen, Chao Li, Menglu Zhu, Xin Liu, Engineering a thermostable version of D-allulose 3-epimerase from Rhodopirellula baltica via site-directed mutagenesis based on B-factors analysis. Enzyme and Microbial Technology, 2020, 132: 109441.

[9]Mao, Shuhong, Guo, Qianqian, Xu, Panpan, Gao, Dengke, Cheng, Xiaotao, Zhu, Menglu, Sun, Dengyue, Zhu, Zhangliang, Lu, Fuping, Qin, Hui-Min. Biochemical and structural characterization of 3-ketosteroid-Delta(1)-dehydrogenase, a candidate enzyme for efficient bioconversion of steroidsJournal of Chemical Technology and Biotechnology, 2019.01: 309-316

[10]Mao, Shuhong, Liu, Yanna, Hou, Yali, Ma, Xiaoyu, Yang, Juanjuan, Han, Haichao, Wu, Jianlin, Jia, Longgang, Qin, Huimin, Lu, Fuping. Efficient production of sugar-derived aldonic acids by Pseudomonas fragi TCCC11892. RSC Advances2018,11: 39897-39901

[11] Mao Shuhong; Li Kang; Hou Yali; Liu Yanna; Ji Shaoxian; Qin Huimin ; Lu FupingSynergistic effects of components in deep eutectic solvents relieve toxicity and improve the performance of steroid biotransformation catalyzed by Arthrobacter simplex Journal of Chemical Technology and Biotechnology 2018,09: 2729-2736.

[12]Mao Shuhong; Wang Xuerong; Ge Zhijiang; Su An; Zhang Lixia; Li Yanqing; Liu Xiaoguang; Lu Fuping, Microbial hydroxylation of 16α,, 17α-epoxyprogesterone by Penicillium decumbens Iranian Journal of Pharmaceutical Research 2017.06.19 16(3) 1161~1166.

[13] Mao Shuhong, Yu Lu; Ji Shaoxian; Liu Xiaoguang; Lu Fuping; Mao Shuhong, Evaluation of deep eutectic solvents as co-solvent for steroids 1-en-dehydrogenation biotransformation by Arthrobactersimplex. Journal of Chemical Technology and Biotechnology, 2016, 91(4): 1099~1104.

[14] Mao Shuhong; Zhang Lixia; Ge Zhijiang; Wang Xuerong; Li Yanqing; Liu, Xiaoguang; Liu Fei; Lu Fuping, Microbial hydroxylation of steroids by Penicillium decumbens, Journal of Molecular Catalysis B: Enzymatic, 2016. S133: 346~S351.

授权发明专利主要有:

[1]毛淑红; 刘晓光; 李慧杰; 李康; 侯亚利 一株生物合成16β-羟基-19-去甲-4-雄烯二酮的菌株及其应用 中国ZL 201810555158.3 (授权专利)

[2]毛淑红; 刘晓光; 王正祥; 路福平; 王雪; 贾龙刚一种诱导型启动子及其用途 中国ZL 201811135123.0 (授权专利)

[3]毛淑红; 路福平; 李玉; 韩海超; 刘艳娜;利用胆碱类低共熔溶剂提高果糖基转移酶催化效率和稳定性的方法 中国ZL201711337279.2 (授权专利)

[4]毛淑红; 路福平; 周瑶; 王娜; 华伯元; 王春霞,一种复合酶法制备茶树菇水解液的方法 中国ZL 201110081576.1(授权专利)

[5]毛淑红; 路福平, 胡晓杰; 刘莎; 李玉; 杜连祥,15α羟基化左旋乙基甾烯双酮的生物制备方法, 中国ZL 201110174200.5 (授权专利)

[6]毛淑红; 路福平; 杜连祥; 蒋彦洁; 别松涛; 王春霞 15α羟基化左旋乙基甾烯双酮的生物制备方法 中国ZL 200910069539.1 (授权专利)

获奖情况

2014年相关研究成果获得天津市科技进步二等奖,排名第四;

2014年,获得天津科技大学“教学质量奖”;

2018年,获天津科技大学“我最喜爱的好导师”称号。

2019年,获评天津市优秀天津市工程专业学位硕士研究生优秀学位论文指导教师

联系方式

办公地点:天津经济技术开发区第十三大街29号天津科技大学生物工程学院

邮政编码:300457

办公电话:022-60602949

真:022-60602298

Email shuhongmao@tust.edu.cn