天津科技大学生物工程学院欢迎您!
教授


韩培培,博士,教授,博士生导师。入选天津市“131”创新性人才计划第二层次、天津市高校中青年骨干创新人才培养计划。现任工业发酵微生物教育部重点实验室副主任,中国食品科学技术学会高级会员,中国微生物学会会员,天津食品学会会员。

学习与工作经历

2001.9-2011.6 天津大学制药工程 学士、博士

2009.9-2011.1 麻省理工学院 国家公派

2011.7-2014.11 天津科技大学生物工程学院 讲师

2014.12-2021.12 天津科技大学生物工程学院 副教授

2022.1至今 天津科技大学生物工程学院 教授

主讲课程:

本科生:酶工程

研究生:合成生物学

主要教学研究及成果情况

参与教改项目1项,发表教改论文4篇,主编或参编教材或专著5部。

[1] 韩培培,贾士儒编著。光调控与发菜细胞培养,科学出版社,2020. (天津市自然科学学术著作出版基金资助

[2] 贾士儒,韩培培主编。奥妙的微生物世界,高等教育出版社,2019.
[3] 贾士儒,韩培培等著。发菜细胞培养,科学出版社,2014 (获天津市科协自然科学学术专著基金出版资助)
[4] 贾士儒主编。生物反应工程原理(第四版),科学出版社,2015(参编)
[5] 贾士儒,宋存江主编。发酵工程实验教程,高等教育出版社,2016(参编)

科研领域及方向

[1] 微生物多糖的生物合成、调控与应用
[2] 天然食品配料的发酵生产
[3] 微藻培养与活性物质开发
[4] 微生物技术的跨学科应用

科研项目情况

[1] 国家自然科学基金面上项目:活性氧通过氧化翻译后修饰调控发菜多糖合成的作用机制研究,项目负责人

[2] 国家自然科学基金面上项目:液体发酵过程发菜多糖生物合成的调控机制研究,项目负责人
[3] 国家自然科学基金青年项目:发状念珠蓝细菌多糖合成代谢的光调控机制研究,项目负责人

[4] 国家重点研发计划项目:工业菌种基因组人工重排技术,子课题负责人

[5] 天津市重点研发计划:港口混凝土结构“自愈合”修复技术及安全性评价应用研究,项目负责人
[6] 国家863计划课题:能源和医药产品模块化设计合成,子课题负责人

[7] 工业发酵微生物教育部重点实验室生工英才培育计划,项目负责人

[8] 横向课题:液体发酵灵芝多糖和灰树花多糖产量提高及其抗氧化、抗辐射活性研究,项目负责人

[9] 横向课题:大型港口结构安全智能监测预警及性能提升关键技术研究与示范应用-微生物 自愈合性能测试,项目负责人
[10] 横向课题:基于微生物矿化的混凝土修复技术开发,项目负责人
[11] 横向课题:海洋环境下混凝土结构生物膜组成研究,项目负责人
[12] 横向课题:淤泥中活性微生物的鉴定分析,项目负责人
[13] 横向课题:海洋环境下混凝土结构生物膜组成研究,项目负责人
[14] 横向课题:微生物对淤泥质港口减淤作用实验,项目负责人
[15] 行业重点实验室开放课题:延缓浮泥沉降的化能自养微生物筛选研究,项目 负责人


主要学术成果

先后以第一作者或通讯作者发表各类科研论文20余篇,申请发明专利37项,其中授权17项,获得科技奖励2项。
近期代表性论文
[1] Xiao-li Wang, Le-leZhang, Ni Chen, Jian Lia, Cheng-feng Han, Shuai Wang, Li-min Hao, Shi-ru Jia, Pei-pei Han*. The effects of quorum sensing molecule farnesol on the yield and activity of extracellular polysaccharide from Grifola frondosa in liquid fermentation.International Journal of Biological Macromolecules, Volume 191, 30 November 2021, Pages 377-384.

[2] Jian Li, Shi-gang Shen, Cheng-feng Han, Shu-ting Liu, Le-le Zhang, Ni Chen, Shi-ru Jia, Pei-pei Han*. Nostoc flagelliforme capsular polysaccharides from different culture conditions improve hyperlipidemia and regulate intestinal flora in C57BL/6J mice to varying degrees. International Journal of Biological Macromolecules 202 (2022) 224233.

[3] Shi-gang Shen, Shi-ru Jia, Yi-kai Wu, Rong-rong Yan, Ya-Hui Lin, Dong-xue Zhao, Pei-pei Han*. Effect of culture conditions on the physicochemical properties and antioxidant activities of polysaccharides from Nostoc flagelliforme. 2018, https://doi.org/10.1016/j.carbpol.2018.06.111 (IF4.811JCR一区)
[4] Pei-pei Han*, Shun-yu Yao, Rong-jun Guo, Shi-gang Shen, Rong-rong Yan, Zhi-lei Tan, Shi-ru Jia*. The relationship between monosaccharide composition of extracellular polysaccharide and activities of related enzymes in Nostoc flagelliforme under different culture conditions. Carbohydrate Polymers 174 (2017) 111–119. (IF4.811JCR一区)
[5] Pei-pei Han*, Shi-gang Shen, Rong-jun Guo, Shun-yu Yao, Ying Sun, Zhi-lei Tan, Shi-ru Jia*. The regulation of photosynthetic pigments in terrestrial Nostoc flagelliforme in response to different light colors. Algal Research 25 (2017) 128–135 (IF5.014JCR二区)
[6] Shi-gang Shen, Shi-ru Jia, Rong-rong Yan, Yi-kai Wu, Hui-yan Wang, Ya-hui Lin, Dong-xue Zhao, Zhi-lei Tan, He-xin Lv and Pei-pei Han*. The physiological responses of terrestrial cyanobacterium Nostoc flagelliforme to different intensities of ultraviolet-B radiation. RSC Advances, 2018, 8, 21065-21074 (IF3.612JCR二区)
[7] Pei-pei Han*, Rong-jun Guo, Shi-gang Shen, Rong-rong Yan, Yi-kai Wu, Shun-yu Yao, Hui-yan Wang, Shi-ru Jia*. Proteomic profiling of Nostoc flagelliforme reveals the common mechanism in promoting polysaccharide production by different light qualities. Biochemical Engineering Journal 132 (2018) 68–78. (IF2.934JCR二区)
[8] Pei-pei Han* Shun-yu Yao, Rong-jun Guo, Rong-rong Yan, Yi-kai Wu, Shi-gang Shen, Shi-ru Jia*. Influence of culture conditions on extracellular polysaccharide production and the activities of enzymes involved in the polysaccharide synthesis of Nostoc flagelliforme. RSC Advances, 2017, 7, 45075-45084 (IF3.612JCR二区)
[9] Pei-pei Han, Shi-gang Shen, Hui-Yan Wang, Shun-yu Yao, Zhi-lei Tan, Cheng Zhong, Shi-ru Jia*. Applying the strategy of light environment control to improve the biomass and polysaccharide production of Nostoc flagelliforme. Journal of Applied Phycology, 2017, 29(1):55-65. (IF2.474JCR二区)
[10] Pei-pei Han, Shi-gang Shen, Hui-Yan Wang, Ying Sun, Yu-jie Dai, Shi-ru Jia*. Comparative metabolomic analysis of the effects of light quality on polysaccharide production of cyanobacterium Nostoc flagelliforme. Algal Research-Biomass Biofuels and Bioproducts, 2015, 9: 143-150. (IF5.014JCR二区)
[11] Pei-pei Han, Shi-gang Shen, Shi-ru Jia, Hui-yan Wang, Cheng Zhong, Zhi-lei Tan, He-xin Lv. Comparison of bacterial community structures of terrestrial cyanobacterium Nostoc flagelliforme in three different regions of China using PCR-DGGE analysis. World Journal of Microbiology and Biotechnology, 2015, 31(7):1061-1069. (IF1.555JCR三区)
[12] Pei-pei Han, Ying Sun, Shi-ru Jia*, Cheng Zhong, Zhi-lei Tan. Effects of light wavelengths on extracellular and capsular polysaccharide production by Nostoc flagelliforme. Carbohydrate Polymers, 2014, 105: 145–151. (IF4.811JCR一区)
[13] Pei-pei Han, Ying Sun, Xiao-ying Wu, Ying-jin Yuan, Yu-jie Dai, Shi-ru Jia*. Emulsifying, Flocculating, and Physicochemical Properties of Exopolysaccharide Produced by Cyanobacterium Nostoc flagelliforme. Applied Biochemistry and Biotechnology, 2014, 172(1): 36-49. (IF1.676JCR三区)
[14] Pei-pei Han, Shi-ru Jia*, Ying Sun, Zhi-lei Tan, Cheng Zhong, Yu-jie Dai, Ning Tan, Shi-gang Shen. Metabolomic approach to optimizing and evaluating antibiotic treatment in the axenic culture of cyanobacterium Nostoc flagelliforme. World Journal of Microbiology & Biotechnology 2014, 30 (9): 2407-2418. (IF1.555JCR三区)
[14] Pei-pei Han, Ting-xiang Ye, Bin Qiao, Ying-jin Yuan*. Taxoids profiling of suspension Taxus chinensis var. mairei cells in response to shear stress. Biochemical Engineering Journal. 2013, 77: 66-73. (IF2.934JCR二区)
[15] Pei-Pei Han and Ying-Jin Yuan*. Lipidomic analysis reveals activation of phospholipid signaling in mechanotransduction of Taxus cuspidata cells in response to shear stress. FASEB Journal. 2009, 23: 623-630. (IF5.280JCR二区top)
[16] Pei-Pei Han and Ying-Jin Yuan*. Metabolic profiling as a tool for understanding defense response of Taxus cuspidata cells to shear stress. Biotechnology Progress. 2009, 25: 1244-1253. (IF2.101JCR二区)
[17] Pei-pei Han, Jian Zhou and Ying-jin Yuan*. Analysis of phospholipids, sterols, and fatty acids in Taxus chinensis var. mairei cells in response to shear stress. Biotechnology and Applied Biochemistry.2009, 54: 105–112. (IF1.401JCR三区)
[18] Tao Bo, Pei-Pei Han, Qin-Zhi Su, Ping Fu, Feng-Zhu Guo, Zuo-Xing Zheng, Zhi-Lei Tan, Cheng Zhong, Shi-Ru Jia*, Antimicrobial epsilon-poly-L-lysine induced changes in cell membrane compositions and properties of Saccharomyces cerevisiae, Food Control, 2016, 61:123-134.
[19] Tao Bo, Miao Liu, Cheng Zhong, Qian Zhang, Qin-zhi Su, Zhi-lei Tan, Pei-pei Han, Shiru Jia. Metabolomic Analysis of Antimicrobial Mechanisms of epsilon-Poly-L-lysine on Saccharomyces cerevisiae. Journal of Agricultural and Food Chemistry, 2014, 62(19): 4454-4465.
[20] Cheng Zhong, Gui-Cai Zhang, Miao Liu, Xin-Tong Zheng, Pei-Pei Han, Shi-Ru Jia*, Metabolic flux analysis of Gluconacetobacter xylinus for bacterial cellulose production, Applied Microbiology and Biotechnology, 2013, 97:6189-6199
[21] Zhen Ding, Shiru Jia, Pei-pei Han, Nannan Yuan, Ning Tan. Effects of carbon sources on growth and extracellular polysaccharide production of Nostoc flagelliforme under heterotrophic high-cell-density fed-batch cultures. Journal of Applied Phycology, 2013, 25(4): 1017-1021
[22] Cheng Zhong, Rui Wang, Zhao Zhou, Shi-Ru Jia*, Zhi-Lei Tan, Pei-Pei Han, Functional properties of protein isolates from Caragana Korshinskii Kom. extracted by three different methods, Journal of Agricultural and Food Chemistry, 2012, 60: 10337-10342

[23] 王帅,赵冬雪,韩成凤,王晓丽,李健,张乐乐,陈旎,韩培培.6 种活性多糖的 结构、性质及其抗氧化活性的比较研究[J].食品科学与研究,2021.

[24] 陈旎,武毅凯,李艳茹,王帅,韩成凤,李健,王晓丽,张乐乐,谭之磊,贾士 儒,韩培培.发菜藻粉对小鼠肠道菌群及免疫调节的影响[J]. 食品科学,2021

[25] 韩培培,贾士儒。发菜细胞培养的研究进展。天津科技大学学报,2016,312):1-5.

近期授权专利与获奖

[1] 韩培培 等,一种高效生产发菜胞外多糖的方法,ZL201810225270.0

[2] 韩培培 等,一株嗜甲基营养菌菌株及其应用,ZL201811053889.4

[3] 韩培培等,用于淤泥质港口减淤的微生物菌剂的制备方法, ZL201811053725.1

[4] 韩培培等,利用微生物矿化制备不同晶型碳酸钙的方法,ZL201811072160.1

[5] 韩培培 等,一种高抗氧化活性灰树花多糖的制备及提纯方法,ZL2021104513938

[6] 天津市科学技术进步二等奖,项目名称:细菌纤维素生物合成调控及其应用,2019

[7] 全国商业科技进步奖三等奖,项目名称:微藻高密度培养联产活性多糖关键技术开发,2019



获奖情况


[1] 国家建设高水平大学公派研究生项目,2009.
[2] 指导2011级、2013级研究生获得国家奖学金
[3] 指导多位大四本科毕业生获得院级优秀毕业论文
[4] 2014年度天津科技大学五比双创教工先锋岗荣誉称号
[5] 2016年度创青春天津科技大学创业大赛优秀指导教师
[6] 2015-2016学年度师生一帮一助学活动先进个人


联系方式
办公地点:天津经济技术开发区第十三大街29号天津科技大学生物工程学院
邮政编码:300457
办公电话:022-60602822
传 真:022-60602298
Emailpphan@tust.edu.cn