天津科技大学生物工程学院欢迎您!
校外导师

郑平,博士,中国科学院天津工业生物技术研究所研究员,博士生导师。天津市滨海新区杰出科技人才。


主讲课程

研究生:《系统生物学在工业生物技术中的应用》

科研领域及方向

[1]系统生物学

[2]合成生物学

长期从事细菌的代谢工程改造和系统生物学研究,利用多组学技术破译工业环境压力下谷氨酸棒杆菌及黑曲霉等工业微生物的代谢和调控机制,揭示菌株生理调控和高产机制之间的关系;致力于利用基因组工程和合成生物学技术创建绿色、高效、低成本的生物制造体系。

科研项目情况

[1] 国家重点研发计划课题:非天然利用有机碳一原料人工细胞的创建,2019-2024

[2] 天津市合成生物技术创新能力提升行动科技攻关项目:氨基酸工业菌株迭代创制,2019-2022

[3] 国家自然基金面上基金:UriR/RbsR参与谷氨酸棒杆菌抵御高温压力的机制研究,2019-2022

[4] 技术委托开发项目:柠檬酸生产菌株高产分析,2017-2017

[5] 技术委托开发项目:生物法生产15-戊二胺中试放大,2017-2019

[6] 863计划课题:基因组理性设计与氨基酸生产菌种的构建,2012-2015

主要学术成果

先后发表各类科研论文60余篇,授权发明专利24项。发表的主要学术论文有:

[1] Yu Wang*, Haijiao Cheng, Yang Liu, Ye Liu, Xiao Wen, Kun Zhang, Xiaomeng Ni, Ning Gao, Liwen Fan, Zhihui Zhang, Jiao Liu, Jiuzhou Chen, Lixian Wang, Yanmei Guo, Ping Zheng*, Meng Wang*, Jibin Sun and Yanhe Ma. In-situ generation of large numbers of genetic combinations for metabolic reprogramming via CRISPR-guided base editing. Nature Communication. https://doi.org/10.1038/s41467-021-21003-y.

[2] Zhihui Zhang, Yu Wang*,Ping Zheng*, and Jibin Sun. Promoting Lignin Valorization by Coping with Toxic C1 Byproducts. Trends in Biotechnology. https://doi.org/10.1016/j.tibtech.2020.09.005

[3] Yu Wang, Liwen Fan, Philibert Tuyishime, Ping Zheng*, Jibin Sun*. Synthetic Methylotrophy: A Practical Solution for Methanol-Based Biomanufacturing. Trends in Biotechnology.2020, 38(6): 650-666.

[4] Xue Sun#, Qinggang Li#, Yu Wang#, Wenjuan Zhou, Yanmei Guo, Jiuzhou Chen, Ping Zheng*, Jibin Sun*, Yanhe Ma. Isoleucyl-tRNA synthetase mutant based whole-cell biosensor for high-throughput selection of isoleucine overproducers. Biosensors and Bioelectronics.2020, 172:112783

[5] Kun Zhang#, Zhihui Zhang#, Jianan Kang, Jiuzhou Chen, Jiao Liu, Ning Gao, Liwen Fan, Ping Zheng*, Yu Wang*, Jibin Sun. CRISPR/Cas13d-Mediated Microbial RNA Knockdown. Frontiers in Bioengineering and Biotechnolog. 2020, 8:856

[6] Mingyue Li#, Jiuzhou Chen#, Yu Wang, Jiao Liu, Jingwen Huang, Ning Chen, Ping Zheng* and Jibin Sun*. Efficient Multiplex Gene Repression by CRISPR-dCpf1 in Corynebacterium glutamicum. Frontiers in Bioengineering and Biotechnology. 2020, 8:357

[7] Yu Wang, Liwen Fan, Philibert Tuyishime, Jiao Liu, Kun Zhang, Ning Gao, Zhihui Zhang, Xiaomeng Ni, Jinhui Feng, Qianqian Yuan, Hongwu Ma, Ping Zheng*, Jibin Sun* and Yanhe Ma. Adaptive laboratory evolution enhances methanol tolerance and conversion in engineered Corynebacterium glutamicum. COMMUNICATIONS BIOLOGY. 2020, 3:1

[8] Yu Wang, Liwen Fan, Philibert Tuyishime, Ping Zheng*, Jibin Sun*. Synthetic Methylotrophy: A Practical Solution for Methanol-Based Biomanufacturing. Trends in Biotechnology. https://doi.org/10.1016/j.tibtech.2019.12.013

[9] Lihui Zhang#, Xiaomei Zheng#, Timothy C. Cairns, Zhidan Zhang, Depei Wang*, Ping Zheng*and Jibin Sun. Disruption or reduced expression of the orotidine‑5′‑decarboxylase gene pyrG increases citric acid production: a new discovery during recyclable genome editing in Aspergillus niger. Microbial Cell Factories. 2020, 19(76).

[10] Jiuzhou Chen#, Yu Wang# , Xuan Guo, Deming Rao, Wenjuan Zhou, Ping Zheng* , Jibin Sun* and Yanhe Ma. Efficient bioproduction of 5‑aminolevulinic acid, a promising biostimulant and nutrient, from renewable bioresources by engineered Corynebacterium glutamicum. Biotechnology for Biofuels. 2020, 13:41.

[11] Taiwo Dele-Osibanjo#, Qinggang Li#, Xiaoli Zhang#, Xuan Guo, Jinhui Feng, Jiao Liu, Xue Sun, Xiaowei Wang, Wenjuan Zhou, Ping Zheng*, Jibin Sun*, Yanhe Ma. Growth-coupled evolution of phosphoketolase to improve l-glutamate production by Corynebacterium glutamicum. Applied Microbiology and Biotechnology. 2019, https://doi.org/10.1007/s00253-019-10043-6

[12] Yu Wang#, Ye Liu#, Junwei Li, Yi Yang, Xiaomeng Ni, Haijiao Cheng, Teng Huang, Yanmei Guo, Hongwu Ma, Ping Zheng*, Meng Wang*, Jibin Sun, Yanhe Ma. Expanding targeting scope, editing window, and base transition capability of base editing in Corynebacterium glutamicum. Biotechnology and Bioengineering. 2019, https://doi.org/10.1002/bit.27121

[13] Xiaowei Wang#, Qinggang Li#, Cunmin Sun, Zhen Cai, Xiaomei Zheng, Xuan Guo, Xiaomeng Ni, Wenjuan Zhou, Yanmei Guo, Ping Zheng*, Ning Chen, Jibin Sun* , Yin Li and Yanhe Ma. GREACE-assisted adaptive laboratory evolution in endpoint fermentation broth enhances lysine production by Escherichia coli. Microbial Cell Factories. 2019, https://doi.org/10.1186/s12934-019-1153-6

[14] Chengchao Zhu#, Jiuzhou Chen#, Yu Wang, Lixian Wang, Xuan Guo, Ning Chen, Ping Zheng*, Jibin Sun*, Yanhe Ma. Enhancing 5aminolevulinic acid tolerance and production by engineering the antioxidant defense system of Escherichia coli. Biotechnology and Bioengineering. 2019, https://doi.org/10.1002/bit.26981

[15] Jiao Liu#, Yu Wang#, Yujiao Lu, xiaomeng Ni, Xuan Guo, Jing Zhao, Jiuzhou Chen, Taiwo Dele-Osibanjo, Ping Zheng*, Jibin Sun*, and Yanhe Ma. Mutations on Peptidoglycan Synthesis Gene ponA Improve Electro-transformation Efficiency of Corynebacterium glutamicum ATCC 13869. Applied and Environmental Microbiology, 2019, 84(24): e02225-18

[16] Xiaomei Zheng, Jiandong Yu, Timothy C. Cairns, Lihui Zhang, Zhidan Zhang, Qiongqiong Zhang, Ping Zheng*, Jibin Sun*, and Yanhe Ma. Comprehensive Improvement of Sample Preparation Methodologies Facilitates Dynamic Metabolomics of Aspergillus niger. Biotechnology Journal, 2019, 14(3): 1800315

[17] Philibert Tuyishime#,Yu Wang#, Liwen Fan, Qiongqiong Zhang, Qinggang Li, Ping Zheng*, Jibin Sun*, Yanhe Ma. Engineering Corynebacterium glutamicum for methanol-dependent growth and glutamate production. Metabolic Engineering, 2018, 49:20-231.

[18] Qiongqiong Zhang#, Xiaomei Zheng#, Yu Wang, Jiandong Yu, Zhidan Zhang, Taiwo Dele-Osibanjo, Ping Zheng*, Jibin Sun*, Shiru Jia, Yanhe Ma. Comprehensive Optimization of the Metabolomics Methodology for Metabolite Profiling of Corynebacterium glutamicum. Applied Microbiology and Biotechnology, 2018, 102 (16): 7113-7121.

[19] Xiaomei Zheng, Ping Zheng*, Kun Zhang, Timothy C. Cairns, Vera Meyer, Jibin Sun*, and Yanhe Ma. 5S rRNA Promoter for Guide RNA Expression Enabled Highly Efficient CRISPR/Cas9 Genome Editing in Aspergillus niger. ACS Synthetic Biology, 2018, e7b00456.

[20] Yu Wang#, Ye Liu#, Jiao Liua, Yanmei Guo, Liwen Fan, Xiaomeng Ni, Xiaomei Zheng, Meng Wang*, Ping Zheng*, Jibin Sun*, Yanhe Ma. MACBETH: Multiplex automated Corynebacterium glutamicum base editing method. Metabolic Engineering, 2018, 47: 200-210.

授权发明专利主要有:

[1] 201310051018.X 。郑平,陈久洲,蒲伟,孙际宾,马延和。5-氨基乙酰丙酸高产菌株及其制备方法和应用

[2] 201410016911.3。郑平,陈久洲,潘丹丹,郭小飞,蒲伟,孙村民,孙际宾,马延和。通过弱化5-氨基乙酰丙酸脱水酶活性获得5-氨基乙酰丙酸高产菌株及其应用

[3] 201410015848.1。郑平,陈久洲,蒲伟,孙际宾,马延和。一种5-氨基乙酰丙酸产生菌株及其制备方法与应用

[4] 201810362420.2。郑平、陈久洲、孙际宾、周文娟、孙村民、郭轩、马延和。5-氨基乙酰丙酸高产菌株及其制备方法和应用

[5] JP6341936B2. Ping Zheng; Jiuzhou Chen; Wei Pu; Jibin Sun; Xinyang Wu; Yanhe Ma. 5 - Aminolevulinic acid-producing strains of use and manufacture thereof

[6] US9896734B2.Guojun Yue; Jibin Sun; Ping Zheng; Jiao Liu; Qinggang Li; Linghe Xia; Yongsheng Zhou; Hu Luo; Yong Zhou; Yun Man; Zongmei Lu; Yanhe Ma.  Asparaginic acid kinase III mutant and host cells and use thereof

[7] 201210398902.6。孙际宾,郑平,刘娇,李庆刚,夏令和,周永生,罗虎,周勇,满云,卢宗梅,马延和。天冬氨酸激酶III突变体及其宿主细胞和应用

[8] 2014107400221。孙际宾,郑平,刘娇,王兴初,彭久合,马延和。一种L-脯氨酸-4-羟基化酶及其应用

[9] 201710380366.X。孙际宾、郑小梅、郑平、马延和。一种新型向导RNA 表达盒及在CRISPR/Cas 系统中的应用

[10] 201910359888.0。孙际宾,李庆刚,郑平,周文娟,张晓立,德莱奥西班乔•泰沃,马延和。活性提高的磷酸转酮酶及在生产代谢物中的应用

获奖情况

研究成果分别获得2014年中国产学研合作创新成果奖,中国科学院科技促进发展奖,中国轻工业联合会科学技术进步二等奖。先后荣获天津市科技系统“女职工建功立业标兵”,滨海新区“131”人才工程二层次人选天津市滨海新区杰出科技人才。

联系方式

办公地点:天津空港经济区西七道32号中国科学院天津工业生物技术研究所

邮政编码:300308

办公电话:022-84861994

传 真:022-84861943

 

Emailzheng_p@tib.cas.cn