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校外导师

朱蕾蕾,博士,中国科学院天津工业生物技术研究所研究员,博士生(硕士生)导师。天津市青年科技工作者协会会员代表。


主讲课程

研究生:工业生物技术

主要教学研究及成果情况

参编专著1部。

[1] Zhu L., Arlt M., Liu H., Schwaneberg U. Chapter 3: Channel protein FhuA as a promising biomolecular scaffold for bioconjugates. Bio-Synthetic Hybrid Materials and Bionanoparticles: A Biological Chemical Approach Towards Material Science. Royal Society of Chemistry,ISBN 9781849738224,2015.

科研领域及方向

[1]聚焦酶蛋白进化设计,发展先进的酶分子改造方法和高通量筛选技术

[2]创制高性能的工业酶和蛋白质,应用于重要化学品的绿色生物制造

科研项目情况

[1] 1. 合成生物学重点研发计划:难降解有毒污染物智能生物降解体系,2019-2024

[2] 国家自然科学基金面上项目:谷氨酸外排蛋白的结构功能关系与性能提升研究,2021-2024

[3] 天津市合成生物技术创新能力提升行动新一代酶制剂真核表达体系,2020-2022.

[4] 天津市自然科学基金:脂肪酶的表面活性剂耐受性研究,2019-2022

[5] 中科院STS项目:污染场地生物修复与塑料废弃物处置技术研究与示范,2019-2020

[6] 中科院重点部署项目:二氧化碳的人工生物合成子课题,2017-2019

[7] 中国科学院-诺和诺德基金:Protein engineering of methionine aminopeptidase (MAP) for robust N-terminal methionine removal from 2018-2020

主要学术成果

先后发表各类科研论文30余篇,申请发明专利10项。代表性学术论文有:

[1] Shi L., Liu H, Gao S., Weng Y.*, Zhu L.*.Enhanced extracellular production of IsPETase in Escherichia coli via engineering of the pelB signal peptide. Journal of Agricultural and Food Chemistry. 2021,DOI:10.1021/acs.jafc.0c07469.

[2] Li T., Tang Z., Wei H., Tan Z., Liu P., Li J., Zheng Y., Lin J., Liu W., Jiang H., Liu H.*, Zhu L.*, Ma Y. Totally atom-economical synthesis of lactic acid from formaldehyde: combined bio-carboligation and chemo-rearrangement without the isolation of intermediate. Green Chemistry, 2020, 22: 6809-6814.

[3] Cheng C., Haider J., Liu P., Yang J., Tan Z., Huang T., Lin J., M. J.*, Liu H.*, Zhu L.*. Engineered LPMO significantly boosting cellulase-catalyzed depolymerization of cellulose. Journal of Agricultural and Food Chemistry. 2020, 68: 1525715266.

[4] Cheng F., Yang J., Schwaneberg U., Zhu L. Rational surface engineering of an arginine deiminase (an antitumor enzyme) for increased PEGylation efficiency. Biotechnology and Bioengineering, 2019, 116(9): 2156-2166.

[5] Cheng F., Yang J., Bocola M., Schwaneberg U., Zhu L. Loop engineering reveals the importance of active-site-decorating loops and gating residue in substrate affinity modulation of arginine deiminase (an anti-tumor enzyme).Biochemical and Biophysical Research Communication. 2018, 499(2): 233-238.

[6] FrauenkronMachedjou V. J., Fulton A., Zhao J., Weber L., Jaege K.E. r, Schwaneberg U., and Zhu L., Exploring the full natural diversity of single amino acid exchange reveals that 40-60% of BSLA positions improve organic solvents resistance. Bioresource and Bioprocessing, 2018, 5:2.

[7] Cheng F.*, Zhu L.*, Schwaneberg U. Directed evolution 2.0: improving and deciphering enzyme properties. Chemical Communication, 2015,51(48):9760-9772.

[8] Cheng F., Kardashliev T., Pitzler C., Shehzad A, Lue H., Bernhagen J, Zhu L. #, Schwaneberg U#. A competitive flow cytometry screening system for directed evolution of therapeutic enzyme. ACS Synthetic Biology, 2015, 4 (7):768-775.


联系方式

办公地点:天津空港经济区西七道32号

邮政编码:300308

办公电话:022-24828796

 

Email: zhu_ll@tib.cas.cn