天津科技大学生物工程学院欢迎您!
校外导师

戴住波博士,中国科学院天津工业生物技术研究所研究员,博士生(硕士生)导师。中国中西医结合学会分子生药学专业委员会秘书,中国中药协会中药发酵药物专业委员会副主任委员。


主讲课程

研究生:分子生药学、天然药物(中药)合成生物学


科研领域及方向

[1] 天然药物(中药)合成生物学研究

[2] 酵母生物学与工程化研究


科研项目情况

[1] 国家重点研发计划子课题,雷公藤内酯等天然产物生物合成未知基因鉴定及途径解析,2021.01-2025.12

[2] 天津市科技重大专项,中药防治新型冠状病毒感染肺炎研究,2020.01-2020.12

[3] 国家重点研发计划课题,重要代谢通路功能再造与高效合成,2019.01-2024.12

[4] 国家重大新药创制专项任务,抗肿瘤化合物β-榄香烯的合成生物学下游技术研究,2018.01-2020.12

[5] 中国科学院重点部署项目课题,丁二酸的生物合成与衍生转化,2013.06-2015.12

[6] 国家自然科学基金,萜类工程菌生物合成途径调控及其表达机制研究,2013.01-2015.12


主要学术成果

研究成果发表在 Metabolic Engineering等TOP学术期刊上,申请专利15项(含PCT 1项),参编《分子生药学》等专著5部。

[1] Dong Wang, Jinhe Wang, Yusong Shi, Rongsheng Li, Feiyu Fan, Yin Huang, Weixian Li, Ning Chen, Luqi Huang, Zhubo Dai* and Xueli Zhang*, Elucidation of the complete biosynthetic pathway of the main triterpene glycosylation products of Panax notoginseng using a synthetic biology platform, Metabolic Engineering, 2020, 61:131-140

[2]  Zhubo Dai#, Yun Liu#, Zhoutong Sun#, Dong Wang, Ge Qu, Lili Zhang, Shoulian Li, Xiaolin Ma, Feiyu Fan, Xueli Zhang*, Identification of a novel cytochrome P450 enzyme that catalyzes the C-2αhydroxylation of pentacyclic triterpenoids and its application in yeast cell factories, Metabolic Engineering, 2019,51:70-78.

[3] Jiajian Huang, Wenlong Zha, Tianyue An,Yin Huang, Dong Wang,Tianyue An, Hua Dong, Rongmin Yu, Lixin Duan, Xueli Zhang, Reuben J. Peters*, Zhubo Dai*, Jiachen Zi*. Identification of RoCYP01(CYP716A155) enables construction of engineered yeast for high-yield production of betulinic acid, Applied Microbiology and Biotechnology, 2019, 103(17):7029-7039

[4] 戴住波,王勇,周志华,李盛英,张学礼*,植物天然产物合成生物学研究,中国科学院院刊, 2018, 33(11):1228-1238.

[5] 王冬, 刘怡, 许骄阳, 王金鹤, 戴住波*, 张学礼, 黄璐琦. 创建酿酒酵母细胞工厂高效生产人参皂苷前体达玛烯二醇II. 药学学报, 2018, 53(8): 1233-1241.

[6]  Zhubo Dai, Yi Liu, Juan Guo, Luqi Huang*, Xueli Zhang*, Yeast synthetic biology for high-value metabolites, FEMS Yeast Research, 2015,15:1-11

[7]    Zhubo Dai#, Beibei Wang#, Yi Liu, Mingyu Shi, Dong Wang, Xianan Zhang, Tao Liu, Luqi Huang*, Xueli Zhang*, Producing aglycons of ginsenosides in bakers' yeast, Scientific Reports, 2014, 4: 3698 2845~2853

[8]    Zhubo Dai#, Yi Liu #, Xianan Zhang, Dong Wang, Luqi Huang*, Xueli Zhang*, Metabolic engineering of Saccharomyces cerevisiae for production of ginsenosides, Metabolic Engineering, 2013, 20:146-156

[9]   Zhubo Dai#, Yi Liu#, Luqi Huang*, Xueli Zhang*, Production of miltiradiene by metabolically engineered Saccharomyces cerevisiae, Biotechnology and Bioengineering, 2012, 109(11): 2845~2853

[10]   Zhubo Dai, Guanghong Cui, Shufeng Zhou* , Xianan Zhang, Luqi Huang*, Cloning and characterization of a novel 3-hydroxy-3-methylglutaryl coenzyme A reductase gene from Salvia miltiorrhiza involved in diterpenoid tanshinone accumulation, Journal of Plant Physiology, 2011, 168(2): 148~157

联系方式

办公地点:天津市空港经济区西七道32

邮政编码:300457

办公电话:022-84861946

传 真:022-84861946

 

Email:dai_zb@tib.cas.cn